Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3357220..3357840 Replicon chromosome
Accession NZ_CP075116
Organism Salmonella enterica subsp. enterica serovar Stanleyville strain CFSAN059881

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CCO40_RS16230 Protein ID WP_001280991.1
Coordinates 3357622..3357840 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CCO40_RS16225 Protein ID WP_000344807.1
Coordinates 3357220..3357594 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO40_RS16215 (3352359) 3352359..3353552 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CCO40_RS16220 (3353575) 3353575..3356724 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
CCO40_RS16225 (3357220) 3357220..3357594 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CCO40_RS16230 (3357622) 3357622..3357840 + 219 WP_001280991.1 HHA domain-containing protein Toxin
CCO40_RS16235 (3358019) 3358019..3358570 + 552 WP_001278792.1 maltose O-acetyltransferase -
CCO40_RS16240 (3358687) 3358687..3359157 + 471 WP_000136181.1 YlaC family protein -
CCO40_RS16245 (3359213) 3359213..3359353 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CCO40_RS16250 (3359359) 3359359..3359619 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CCO40_RS16255 (3359843) 3359843..3361393 + 1551 WP_000213139.1 EAL domain-containing protein -
CCO40_RS16265 (3361624) 3361624..3362013 + 390 WP_000961285.1 MGMT family protein -
CCO40_RS16270 (3362046) 3362046..3362615 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202985 WP_001280991.1 NZ_CP075116:3357622-3357840 [Salmonella enterica subsp. enterica serovar Stanleyville]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202985 NZ_CP099808:c1009173-1008970 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202985 WP_000344807.1 NZ_CP075116:3357220-3357594 [Salmonella enterica subsp. enterica serovar Stanleyville]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202985 NZ_CP099808:c1009593-1009225 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References