Detailed information of TA system TA202974

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 836836..837496
• Replicon: chromosome
• Accession: NZ_CP075116
• Organism: Salmonella enterica subsp. enterica serovar Stanleyville strain CFSAN059881

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A3Y0E4E4
• Locus tag: CCO40_RS04040
• Protein ID: WP_000244757.1
• Coordinates: 837083..837496 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: CCO40_RS04035
• Protein ID: WP_000351186.1
• Coordinates: 836836..837102 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO40_RS04015 (832765)	832765..834198	-	1434	WP_094889076.1	6-phospho-beta-glucosidase BglA	-
CCO40_RS04020 (834356)	834356..834667	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
CCO40_RS04025 (834831)	834831..835490	+	660	WP_094889077.1	hemolysin III family protein	-
CCO40_RS04030 (835606)	835606..836586	-	981	WP_000874176.1	tRNA-modifying protein YgfZ	-
CCO40_RS04035 (836836)	836836..837102	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
CCO40_RS04040 (837083)	837083..837496	+	414	WP_000244757.1	protein YgfX	Toxin
CCO40_RS04045 (837549)	837549..838070	-	522	WP_001055885.1	flavodoxin FldB	-
CCO40_RS04050 (838183)	838183..839079	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
CCO40_RS04055 (839103)	839103..839816	+	714	WP_000745623.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
CCO40_RS04060 (839822)	839822..841555	+	1734	WP_000813394.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16282.29 Da
• Isoelectric Point: 11.1741

>T202974 WP_000244757.1 NZ_CP075116:837083-837496 [Salmonella enterica subsp. enterica serovar Stanleyville]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Nucleotide

• Length: 414 bp

>T202974 NZ_CP099801:2372494-2373231 [Bacillus paranthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAATACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACATCAATCATTCAAAATGTCAATCCAGTAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGTATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT202974 WP_000351186.1 NZ_CP075116:836836-837102 [Salmonella enterica subsp. enterica serovar Stanleyville]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT202974 NZ_CP099801:2373344-2373469 [Bacillus paranthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: A0A3Y0E4E4

Antitoxin

• AlphaFold DB: A0A5I0YWH4