Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 208371..209131 Replicon chromosome
Accession NZ_CP075116
Organism Salmonella enterica subsp. enterica serovar Stanleyville strain CFSAN059881

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag CCO40_RS00980 Protein ID WP_000533909.1
Coordinates 208646..209131 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag CCO40_RS00975 Protein ID WP_000965886.1
Coordinates 208371..208658 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO40_RS00950 (203666) 203666..203968 + 303 WP_000605590.1 YsaB family lipoprotein -
CCO40_RS00955 (204107) 204107..205018 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
CCO40_RS00960 (205028) 205028..207097 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
CCO40_RS00965 (207279) 207279..207554 + 276 Protein_191 IS3 family transposase -
CCO40_RS00970 (207726) 207726..208193 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
CCO40_RS00975 (208371) 208371..208658 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
CCO40_RS00980 (208646) 208646..209131 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
CCO40_RS00985 (209503) 209503..210042 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
CCO40_RS00990 (210216) 210216..210428 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CCO40_RS00995 (210717) 210717..211007 - 291 WP_000455790.1 HTH-type transcriptional regulator -
CCO40_RS01000 (211445) 211445..212155 + 711 WP_000190524.1 DUF3053 domain-containing protein -
CCO40_RS01005 (212205) 212205..213179 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
CCO40_RS01010 (213398) 213398..214060 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T202971 WP_000533909.1 NZ_CP075116:208646-209131 [Salmonella enterica subsp. enterica serovar Stanleyville]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202971 NZ_CP099798:c4718594-4718247 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT202971 WP_000965886.1 NZ_CP075116:208371-208658 [Salmonella enterica subsp. enterica serovar Stanleyville]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202971 NZ_CP099798:c4718855-4718604 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References