Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4079201..4079982 Replicon chromosome
Accession NZ_CP075115
Organism Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag CCO38_RS19670 Protein ID WP_000625912.1
Coordinates 4079201..4079692 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag CCO38_RS19675 Protein ID WP_001110450.1
Coordinates 4079689..4079982 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO38_RS19645 (4074332) 4074332..4076770 - 2439 WP_031601975.1 F4 (K88) fimbrial usher FaeD -
CCO38_RS19650 (4076780) 4076780..4077319 - 540 WP_023251768.1 type 1 fimbrial protein -
CCO38_RS19655 (4077354) 4077354..4077638 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
CCO38_RS19660 (4078231) 4078231..4078458 + 228 WP_060633367.1 hypothetical protein -
CCO38_RS19665 (4078733) 4078733..4078966 - 234 Protein_3870 IS481 family transposase -
CCO38_RS19670 (4079201) 4079201..4079692 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
CCO38_RS19675 (4079689) 4079689..4079982 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
CCO38_RS22115 (4080300) 4080300..4080522 + 223 Protein_3873 hypothetical protein -
CCO38_RS19680 (4080786) 4080786..4081661 + 876 WP_094915479.1 AraC family transcriptional regulator -
CCO38_RS19685 (4081658) 4081658..4081945 + 288 WP_001269916.1 transcriptional regulator RtsB -
CCO38_RS22120 (4081938) 4081938..4082120 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
CCO38_RS22125 (4082140) 4082140..4082239 + 100 Protein_3877 hypothetical protein -
CCO38_RS22130 (4082350) 4082350..4082484 + 135 Protein_3878 hypothetical protein -
CCO38_RS19695 (4082779) 4082779..4083684 - 906 WP_023220383.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4066916..4082120 15204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T202968 WP_000625912.1 NZ_CP075115:c4079692-4079201 [Salmonella enterica subsp. enterica serovar Eastbourne]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T202968 NZ_CP099798:1856075-1856662 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT202968 WP_001110450.1 NZ_CP075115:c4079982-4079689 [Salmonella enterica subsp. enterica serovar Eastbourne]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202968 NZ_CP099798:1856729-1857583 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGACAGCCTGGAAACCCAGACCCGCTGGCGTGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCATCCTTGACGATCTACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References