Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3940629..3941145 Replicon chromosome
Accession NZ_CP075115
Organism Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883

Toxin (Protein)


Gene name relE Uniprot ID A0A4U8A1S0
Locus tag CCO38_RS18950 Protein ID WP_001631980.1
Coordinates 3940629..3940913 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4U8IVQ1
Locus tag CCO38_RS18955 Protein ID WP_001631979.1
Coordinates 3940903..3941145 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO38_RS18935 (3935745) 3935745..3937397 + 1653 WP_023233270.1 alpha,alpha-phosphotrehalase -
CCO38_RS18940 (3937806) 3937806..3939944 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
CCO38_RS18945 (3940161) 3940161..3940625 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CCO38_RS18950 (3940629) 3940629..3940913 - 285 WP_001631980.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCO38_RS18955 (3940903) 3940903..3941145 - 243 WP_001631979.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CCO38_RS18960 (3941223) 3941223..3943136 - 1914 WP_023233269.1 BglG family transcription antiterminator -
CCO38_RS18965 (3943153) 3943153..3943893 - 741 WP_000779262.1 KDGP aldolase family protein -
CCO38_RS18970 (3943890) 3943890..3945008 - 1119 WP_001139165.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CCO38_RS18975 (3944992) 3944992..3946125 - 1134 WP_000459925.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10820.65 Da        Isoelectric Point: 10.0482

>T202967 WP_001631980.1 NZ_CP075115:c3940913-3940629 [Salmonella enterica subsp. enterica serovar Eastbourne]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVLVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202967 NZ_CP099798:1589592-1590461 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8975.37 Da        Isoelectric Point: 5.0807

>AT202967 WP_001631979.1 NZ_CP075115:c3941145-3940903 [Salmonella enterica subsp. enterica serovar Eastbourne]
MATLNVRLDEKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202967 NZ_CP099798:1590454-1591287 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U8A1S0

Antitoxin

Source ID Structure
AlphaFold DB A0A4U8IVQ1

References