Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 3881530..3882080 | Replicon | chromosome |
| Accession | NZ_CP075115 | ||
| Organism | Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A5J1IE68 |
| Locus tag | CCO38_RS18640 | Protein ID | WP_023212786.1 |
| Coordinates | 3881530..3881838 (-) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7RP97 |
| Locus tag | CCO38_RS18645 | Protein ID | WP_001118105.1 |
| Coordinates | 3881841..3882080 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCO38_RS18610 (3877021) | 3877021..3879468 | + | 2448 | WP_052942568.1 | AAA family ATPase | - |
| CCO38_RS18615 (3879764) | 3879764..3880072 | + | 309 | WP_023212781.1 | RAQPRD family integrative conjugative element protein | - |
| CCO38_RS18620 (3880065) | 3880065..3880298 | + | 234 | WP_023212782.1 | TIGR03758 family integrating conjugative element protein | - |
| CCO38_RS18625 (3880308) | 3880308..3880625 | + | 318 | WP_023212783.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| CCO38_RS18630 (3880627) | 3880627..3880866 | + | 240 | WP_023212784.1 | DUF3487 family protein | - |
| CCO38_RS22100 (3880817) | 3880817..3880981 | + | 165 | WP_238705881.1 | DUF3487 family protein | - |
| CCO38_RS18635 (3880978) | 3880978..3881496 | + | 519 | Protein_3668 | TIGR03746 family integrating conjugative element protein | - |
| CCO38_RS18640 (3881530) | 3881530..3881838 | - | 309 | WP_023212786.1 | CcdB family protein | Toxin |
| CCO38_RS18645 (3881841) | 3881841..3882080 | - | 240 | WP_001118105.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| CCO38_RS18650 (3882189) | 3882189..3882437 | - | 249 | WP_023212787.1 | ribbon-helix-helix domain-containing protein | - |
| CCO38_RS18655 (3882514) | 3882514..3883347 | - | 834 | WP_023212788.1 | DUF4942 domain-containing protein | - |
| CCO38_RS18660 (3883489) | 3883489..3883806 | - | 318 | Protein_3673 | toxin | - |
| CCO38_RS18665 (3883821) | 3883821..3884150 | - | 330 | WP_023212789.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| CCO38_RS18670 (3884213) | 3884213..3884713 | - | 501 | WP_023212790.1 | DNA repair protein RadC | - |
| CCO38_RS18675 (3884726) | 3884726..3885366 | - | 641 | Protein_3676 | DUF945 domain-containing protein | - |
| CCO38_RS18680 (3885451) | 3885451..3886371 | - | 921 | WP_023212792.1 | hypothetical protein | - |
| CCO38_RS18685 (3886436) | 3886436..3886639 | - | 204 | WP_000508162.1 | hypothetical protein | - |
| CCO38_RS18690 (3886656) | 3886656..3886802 | - | 147 | WP_023892166.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3872204..3901279 | 29075 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11859.69 Da Isoelectric Point: 6.7228
>T202966 WP_023212786.1 NZ_CP075115:c3881838-3881530 [Salmonella enterica subsp. enterica serovar Eastbourne]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLINNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLINNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
Download Length: 309 bp
>T202966 NZ_CP099798:c143848-143567 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8719.90 Da Isoelectric Point: 6.4633
>AT202966 WP_001118105.1 NZ_CP075115:c3882080-3881841 [Salmonella enterica subsp. enterica serovar Eastbourne]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF
Download Length: 240 bp
>AT202966 NZ_CP099798:c144072-143845 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5J1IE68 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H9SZK8 |