Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3252586..3253206 Replicon chromosome
Accession NZ_CP075115
Organism Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CCO38_RS15745 Protein ID WP_001280991.1
Coordinates 3252988..3253206 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CCO38_RS15740 Protein ID WP_000344807.1
Coordinates 3252586..3252960 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO38_RS15730 (3247725) 3247725..3248918 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CCO38_RS15735 (3248941) 3248941..3252090 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
CCO38_RS15740 (3252586) 3252586..3252960 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CCO38_RS15745 (3252988) 3252988..3253206 + 219 WP_001280991.1 HHA domain-containing protein Toxin
CCO38_RS15750 (3253385) 3253385..3253936 + 552 WP_023251911.1 maltose O-acetyltransferase -
CCO38_RS15755 (3254054) 3254054..3254524 + 471 WP_000136183.1 YlaC family protein -
CCO38_RS15760 (3254580) 3254580..3254720 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CCO38_RS15765 (3254726) 3254726..3254986 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CCO38_RS15770 (3255211) 3255211..3256761 + 1551 WP_001642888.1 EAL domain-containing protein -
CCO38_RS15780 (3256992) 3256992..3257381 + 390 WP_000961285.1 MGMT family protein -
CCO38_RS15785 (3257414) 3257414..3257983 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202965 WP_001280991.1 NZ_CP075115:3252988-3253206 [Salmonella enterica subsp. enterica serovar Eastbourne]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202965 NZ_CP099797:c5196383-5196105 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202965 WP_000344807.1 NZ_CP075115:3252586-3252960 [Salmonella enterica subsp. enterica serovar Eastbourne]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202965 NZ_CP099797:c5196093-5195788 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References