Detailed information of TA system TA202964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2274290..2274812
• Replicon: chromosome
• Accession: NZ_CP075115
• Organism: Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A5J1ICX1
• Locus tag: CCO38_RS10910
• Protein ID: WP_000221344.1
• Coordinates: 2274528..2274812 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: CCO38_RS10905
• Protein ID: WP_000885424.1
• Coordinates: 2274290..2274538 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO38_RS21985 (2270306)	2270306..2270413	+	108	Protein_2136	hypothetical protein	-
CCO38_RS10880 (2270659)	2270659..2271639	-	981	WP_000876799.1	nitronate monooxygenase	-
CCO38_RS10885 (2271813)	2271813..2272721	-	909	WP_001176638.1	LysR family transcriptional regulator	-
CCO38_RS10890 (2273123)	2273123..2273326	+	204	WP_001276024.1	DUF29 family protein	-
CCO38_RS10895 (2273601)	2273601..2273933	-	333	WP_000253078.1	DUF1493 family protein	-
CCO38_RS10900 (2274019)	2274019..2274138	-	120	Protein_2141	type II and III secretion system	-
CCO38_RS10905 (2274290)	2274290..2274538	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CCO38_RS10910 (2274528)	2274528..2274812	+	285	WP_000221344.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCO38_RS10915 (2274931)	2274931..2275212	+	282	Protein_2144	RidA family protein	-
CCO38_RS10920 (2275264)	2275264..2276343	-	1080	WP_000954692.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
CCO38_RS10925 (2276536)	2276536..2277024	-	489	WP_001293645.1	MarR family winged helix-turn-helix transcriptional regulator	-
CCO38_RS10930 (2277069)	2277069..2278577	+	1509	WP_000199418.1	FAD-dependent oxidoreductase	-
CCO38_RS10935 (2278567)	2278567..2279808	+	1242	WP_023233324.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11015.73 Da
• Isoelectric Point: 10.5388

>T202964 WP_000221344.1 NZ_CP075115:2274528-2274812 [Salmonella enterica subsp. enterica serovar Eastbourne]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Nucleotide

• Length: 285 bp

>T202964 NZ_CP099797:c4718619-4718272 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT202964 WP_000885424.1 NZ_CP075115:2274290-2274538 [Salmonella enterica subsp. enterica serovar Eastbourne]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT202964 NZ_CP099797:c4718880-4718629 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Structures

Toxin

• AlphaFold DB: A0A5J1ICX1

Antitoxin

• AlphaFold DB: A0A5I0WPN5