Detailed information of TA system TA202955

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 814642..815302
• Replicon: chromosome
• Accession: NZ_CP075115
• Organism: Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: Q57K70
• Locus tag: CCO38_RS03935
• Protein ID: WP_000244756.1
• Coordinates: 814889..815302 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: CCO38_RS03930
• Protein ID: WP_000351186.1
• Coordinates: 814642..814908 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO38_RS03910 (810570)	810570..812003	-	1434	WP_001230152.1	6-phospho-beta-glucosidase BglA	-
CCO38_RS03915 (812162)	812162..812473	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
CCO38_RS03920 (812637)	812637..813296	+	660	WP_000250289.1	hemolysin III family protein	-
CCO38_RS03925 (813412)	813412..814392	-	981	WP_000874169.1	tRNA-modifying protein YgfZ	-
CCO38_RS03930 (814642)	814642..814908	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
CCO38_RS03935 (814889)	814889..815302	+	414	WP_000244756.1	protein YgfX	Toxin
CCO38_RS03940 (815355)	815355..815876	-	522	WP_001055885.1	flavodoxin FldB	-
CCO38_RS03945 (815989)	815989..816885	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
CCO38_RS03950 (816909)	816909..817622	+	714	WP_000745614.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
CCO38_RS03955 (817628)	817628..819361	+	1734	WP_000813394.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16183.15 Da
• Isoelectric Point: 10.7537

>T202955 WP_000244756.1 NZ_CP075115:814889-815302 [Salmonella enterica subsp. enterica serovar Eastbourne]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T202955 NZ_CP099754:c4702367-4701981 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT202955 WP_000351186.1 NZ_CP075115:814642-814908 [Salmonella enterica subsp. enterica serovar Eastbourne]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT202955 NZ_CP099754:c4702906-4702397 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGTCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCATAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Structures

Toxin

• AlphaFold DB: A0A3Z1E9V5

Antitoxin

• AlphaFold DB: A0A5I0YWH4