Detailed information of TA system TA202954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 312662..313248
• Replicon: chromosome
• Accession: NZ_CP075115
• Organism: Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q57IR9
• Locus tag: CCO38_RS01455
• Protein ID: WP_000174963.1
• Coordinates: 312880..313248 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: CCO38_RS01450
• Protein ID: WP_001635839.1
• Coordinates: 312662..312883 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO38_RS01425 (307683)	307683..308792	+	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
CCO38_RS01430 (308852)	308852..309778	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
CCO38_RS01435 (309775)	309775..311052	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
CCO38_RS01440 (311049)	311049..311816	+	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
CCO38_RS01445 (311818)	311818..312531	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
CCO38_RS01450 (312662)	312662..312883	+	222	WP_001635839.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CCO38_RS01455 (312880)	312880..313248	+	369	WP_000174963.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
CCO38_RS01460 (313507)	313507..314823	+	1317	WP_000624747.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
CCO38_RS01465 (314928)	314928..315815	+	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
CCO38_RS01470 (315812)	315812..316657	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
CCO38_RS01475 (316660)	316660..317730	+	1071	WP_000907842.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	307683..318467	10784

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13573.85 Da
• Isoelectric Point: 6.7252

>T202954 WP_000174963.1 NZ_CP075115:312880-313248 [Salmonella enterica subsp. enterica serovar Eastbourne]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T202954 NZ_CP099754:c4576991-4576818 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8176.21 Da
• Isoelectric Point: 5.0775

>AT202954 WP_001635839.1 NZ_CP075115:312662-312883 [Salmonella enterica subsp. enterica serovar Eastbourne]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKPAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT202954 NZ_CP099754:c4577315-4577019 [Escherichia coli]
ATGGAAGGTAAAAATAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A5H6KCD5