Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 207810..208570 Replicon chromosome
Accession NZ_CP075115
Organism Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag CCO38_RS00975 Protein ID WP_000533909.1
Coordinates 208085..208570 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag CCO38_RS00970 Protein ID WP_000965886.1
Coordinates 207810..208097 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO38_RS21880 (203809) 203809..204228 + 420 Protein_189 IS3 family transposase -
CCO38_RS21885 (204387) 204387..205175 + 789 Protein_190 IS3 family transposase -
CCO38_RS00960 (205488) 205488..206480 + 993 WP_001528230.1 HNH endonuclease -
CCO38_RS00965 (206551) 206551..207177 - 627 WP_130559547.1 hypothetical protein -
CCO38_RS00970 (207810) 207810..208097 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
CCO38_RS00975 (208085) 208085..208570 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
CCO38_RS00980 (208942) 208942..209481 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
CCO38_RS00985 (209654) 209654..209866 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CCO38_RS00990 (210154) 210154..210444 - 291 WP_000455790.1 HTH-type transcriptional regulator -
CCO38_RS00995 (210883) 210883..211593 + 711 WP_000190524.1 DUF3053 domain-containing protein -
CCO38_RS01000 (211643) 211643..212617 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
CCO38_RS01005 (212847) 212847..213509 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T202953 WP_000533909.1 NZ_CP075115:208085-208570 [Salmonella enterica subsp. enterica serovar Eastbourne]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202953 NZ_CP099754:4565481-4565855 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT202953 WP_000965886.1 NZ_CP075115:207810-208097 [Salmonella enterica subsp. enterica serovar Eastbourne]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202953 NZ_CP099754:4565023-4565391 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References