Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 45443..45968 | Replicon | plasmid pCFSAN059898 |
| Accession | NZ_CP075114 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain CFSAN059898 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | CCO47_RS23845 | Protein ID | WP_001159863.1 |
| Coordinates | 45663..45968 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | CCO47_RS23840 | Protein ID | WP_000813641.1 |
| Coordinates | 45443..45661 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCO47_RS23805 (CCO47_23805) | 40470..41183 | + | 714 | WP_000801115.1 | hypothetical protein | - |
| CCO47_RS23810 (CCO47_23810) | 41308..41892 | + | 585 | WP_001575501.1 | hypothetical protein | - |
| CCO47_RS23815 (CCO47_23815) | 41965..42177 | + | 213 | WP_000063794.1 | FaeA/PapI family transcriptional regulator | - |
| CCO47_RS23820 (CCO47_23820) | 42438..42599 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| CCO47_RS23825 (CCO47_23825) | 42625..43473 | + | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| CCO47_RS23830 (CCO47_23830) | 44043..44471 | - | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | - |
| CCO47_RS23835 (CCO47_23835) | 44468..44698 | - | 231 | WP_001261283.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| CCO47_RS23840 (CCO47_23840) | 45443..45661 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| CCO47_RS23845 (CCO47_23845) | 45663..45968 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| CCO47_RS23850 (CCO47_23850) | 45970..46260 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| CCO47_RS23855 (CCO47_23855) | 46257..46778 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| CCO47_RS23860 (CCO47_23860) | 46813..47595 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| CCO47_RS23865 (CCO47_23865) | 47604..48317 | + | 714 | WP_000545756.1 | EAL domain-containing protein | - |
| CCO47_RS23870 (CCO47_23870) | 48342..48830 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| CCO47_RS23875 (CCO47_23875) | 48824..49160 | + | 337 | Protein_61 | hypothetical protein | - |
| CCO47_RS24340 | 49070..49492 | + | 423 | WP_225236769.1 | LysM peptidoglycan-binding domain-containing protein | - |
| CCO47_RS23880 (CCO47_23880) | 49387..49932 | + | 546 | WP_071591236.1 | inverse autotransporter beta domain-containing protein | - |
| CCO47_RS23885 (CCO47_23885) | 49999..50385 | - | 387 | WP_012301160.1 | helix-turn-helix domain-containing protein | - |
| CCO47_RS23890 (CCO47_23890) | 50442..50867 | + | 426 | WP_000064919.1 | IS200/IS605 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | faeH / faeI / spvC / spvB | 1..74688 | 74688 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T202952 WP_001159863.1 NZ_CP075114:45663-45968 [Salmonella enterica subsp. enterica serovar Dublin]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T202952 NZ_CP099754:c4432013-4431663 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT202952 WP_000813641.1 NZ_CP075114:45443-45661 [Salmonella enterica subsp. enterica serovar Dublin]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT202952 NZ_CP099754:c4432258-4432007 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |