Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 44043..44698 | Replicon | plasmid pCFSAN059898 |
| Accession | NZ_CP075114 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain CFSAN059898 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | M7RF18 |
| Locus tag | CCO47_RS23830 | Protein ID | WP_000812999.1 |
| Coordinates | 44043..44471 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | H9AC95 |
| Locus tag | CCO47_RS23835 | Protein ID | WP_001261283.1 |
| Coordinates | 44468..44698 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCO47_RS23795 (CCO47_23795) | 39444..40208 | + | 765 | WP_000827659.1 | K88 minor fimbrial subunit faeI | - |
| CCO47_RS23800 (CCO47_23800) | 40195..40470 | + | 276 | WP_001020576.1 | hypothetical protein | - |
| CCO47_RS23805 (CCO47_23805) | 40470..41183 | + | 714 | WP_000801115.1 | hypothetical protein | - |
| CCO47_RS23810 (CCO47_23810) | 41308..41892 | + | 585 | WP_001575501.1 | hypothetical protein | - |
| CCO47_RS23815 (CCO47_23815) | 41965..42177 | + | 213 | WP_000063794.1 | FaeA/PapI family transcriptional regulator | - |
| CCO47_RS23820 (CCO47_23820) | 42438..42599 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| CCO47_RS23825 (CCO47_23825) | 42625..43473 | + | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| CCO47_RS23830 (CCO47_23830) | 44043..44471 | - | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| CCO47_RS23835 (CCO47_23835) | 44468..44698 | - | 231 | WP_001261283.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| CCO47_RS23840 (CCO47_23840) | 45443..45661 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| CCO47_RS23845 (CCO47_23845) | 45663..45968 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | - |
| CCO47_RS23850 (CCO47_23850) | 45970..46260 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| CCO47_RS23855 (CCO47_23855) | 46257..46778 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| CCO47_RS23860 (CCO47_23860) | 46813..47595 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| CCO47_RS23865 (CCO47_23865) | 47604..48317 | + | 714 | WP_000545756.1 | EAL domain-containing protein | - |
| CCO47_RS23870 (CCO47_23870) | 48342..48830 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| CCO47_RS23875 (CCO47_23875) | 48824..49160 | + | 337 | Protein_61 | hypothetical protein | - |
| CCO47_RS24340 | 49070..49492 | + | 423 | WP_225236769.1 | LysM peptidoglycan-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | faeH / faeI / spvC / spvB | 1..74688 | 74688 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15483.03 Da Isoelectric Point: 7.6736
>T202951 WP_000812999.1 NZ_CP075114:c44471-44043 [Salmonella enterica subsp. enterica serovar Dublin]
MKQPRTKTYMLDTCICSFIMREQSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS
MKQPRTKTYMLDTCICSFIMREQSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS
Download Length: 429 bp
>T202951 NZ_CP099754:c4357581-4357294 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8737.83 Da Isoelectric Point: 4.3775
>AT202951 WP_001261283.1 NZ_CP075114:c44698-44468 [Salmonella enterica subsp. enterica serovar Dublin]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
Download Length: 231 bp
>AT202951 NZ_CP099754:c4357307-4357005 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | M7RF18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6X6R7C5 |