202941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3545808..3546428 Replicon chromosome
Accession NZ_CP075113
Organism Salmonella enterica subsp. enterica serovar Dublin strain CFSAN059898

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CCO47_RS17540 Protein ID WP_001280991.1
Coordinates 3546210..3546428 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CCO47_RS17535 Protein ID WP_000344807.1
Coordinates 3545808..3546182 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO47_RS17525 (3540947) 3540947..3542140 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CCO47_RS17530 (3542163) 3542163..3545312 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
CCO47_RS17535 (3545808) 3545808..3546182 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CCO47_RS17540 (3546210) 3546210..3546428 + 219 WP_001280991.1 HHA domain-containing protein Toxin
CCO47_RS17545 (3546607) 3546607..3547158 + 552 WP_001278787.1 maltose O-acetyltransferase -
CCO47_RS17550 (3547276) 3547276..3547746 + 471 WP_000136183.1 YlaC family protein -
CCO47_RS17555 (3547802) 3547802..3547942 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CCO47_RS17560 (3547948) 3547948..3548208 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CCO47_RS17565 (3548433) 3548433..3549983 + 1551 WP_000213140.1 EAL domain-containing protein -
CCO47_RS17575 (3550214) 3550214..3550603 + 390 WP_000961287.1 MGMT family protein -
CCO47_RS17580 (3550636) 3550636..3551205 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202941 WP_001280991.1 NZ_CP075113:3546210-3546428 [Salmonella enterica subsp. enterica serovar Dublin]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202941 NZ_CP099754:2206327-2206430 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202941 WP_000344807.1 NZ_CP075113:3545808-3546182 [Salmonella enterica subsp. enterica serovar Dublin]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202941 NZ_CP099754:c2206468-2206197 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References