Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824313..824973 Replicon chromosome
Accession NZ_CP075113
Organism Salmonella enterica subsp. enterica serovar Dublin strain CFSAN059898

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag CCO47_RS03980 Protein ID WP_000244756.1
Coordinates 824560..824973 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag CCO47_RS03975 Protein ID WP_000351186.1
Coordinates 824313..824579 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO47_RS03955 (820244) 820244..821677 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
CCO47_RS03960 (821832) 821832..822146 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
CCO47_RS03965 (822308) 822308..822967 + 660 WP_000250289.1 hemolysin III family protein -
CCO47_RS03970 (823083) 823083..824063 - 981 WP_000874174.1 tRNA-modifying protein YgfZ -
CCO47_RS03975 (824313) 824313..824579 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
CCO47_RS03980 (824560) 824560..824973 + 414 WP_000244756.1 protein YgfX Toxin
CCO47_RS03985 (825026) 825026..825547 - 522 WP_001055885.1 flavodoxin FldB -
CCO47_RS03990 (825660) 825660..826556 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
CCO47_RS03995 (826580) 826580..827293 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CCO47_RS04000 (827299) 827299..829032 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T202930 WP_000244756.1 NZ_CP075113:824560-824973 [Salmonella enterica subsp. enterica serovar Dublin]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T202930 NZ_CP099752:3993789-3994124 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202930 WP_000351186.1 NZ_CP075113:824313-824579 [Salmonella enterica subsp. enterica serovar Dublin]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202930 NZ_CP099752:3993541-3993789 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References