Detailed information of TA system TA202925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4600267..4600883
• Replicon: chromosome
• Accession: NZ_CP075112
• Organism: Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q8Z2U3
• Locus tag: CCO42_RS21920
• Protein ID: WP_000238494.1
• Coordinates: 4600267..4600641 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: CCO42_RS21925
• Protein ID: WP_001523745.1
• Coordinates: 4600641..4600883 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO42_RS21905 (4597769)	4597769..4598671	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
CCO42_RS21910 (4598668)	4598668..4599303	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
CCO42_RS21915 (4599300)	4599300..4600229	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
CCO42_RS21920 (4600267)	4600267..4600641	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCO42_RS21925 (4600641)	4600641..4600883	-	243	WP_001523745.1	CopG family transcriptional regulator	Antitoxin
CCO42_RS21930 (4601088)	4601088..4602017	+	930	WP_063809158.1	alpha/beta hydrolase	-
CCO42_RS21935 (4602103)	4602103..4602414	+	312	WP_063809159.1	type II toxin-antitoxin system HigB family toxin	-
CCO42_RS21940 (4602411)	4602411..4602857	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
CCO42_RS21945 (4602872)	4602872..4603813	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
CCO42_RS21950 (4603858)	4603858..4604295	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
CCO42_RS21955 (4604292)	4604292..4605164	-	873	WP_000921423.1	virulence factor BrkB family protein	-
CCO42_RS21960 (4605158)	4605158..4605757	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13908.18 Da
• Isoelectric Point: 7.3567

>T202925 WP_000238494.1 NZ_CP075112:c4600641-4600267 [Salmonella enterica subsp. enterica serovar Corvallis]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Nucleotide

• Length: 375 bp

>T202925 NZ_CP099752:c2504353-2504180 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT202925 WP_001523745.1 NZ_CP075112:c4600883-4600641 [Salmonella enterica subsp. enterica serovar Corvallis]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT202925 NZ_CP099752:c2504677-2504381 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A5I6CND8