Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4289418..4290199 | Replicon | chromosome |
| Accession | NZ_CP075112 | ||
| Organism | Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A5I1HVL4 |
| Locus tag | CCO42_RS20535 | Protein ID | WP_023255089.1 |
| Coordinates | 4289418..4289909 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | A0A3V4SIN7 |
| Locus tag | CCO42_RS20540 | Protein ID | WP_001110453.1 |
| Coordinates | 4289906..4290199 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCO42_RS20505 (4285067) | 4285067..4285816 | - | 750 | WP_001747728.1 | PTS sugar transporter subunit IIC | - |
| CCO42_RS20510 (4285869) | 4285869..4286351 | - | 483 | WP_000108907.1 | PTS sugar transporter subunit IIB | - |
| CCO42_RS20515 (4286369) | 4286369..4286758 | - | 390 | WP_001747727.1 | mannose/fructose/sorbose PTS transporter subunit IIA | - |
| CCO42_RS20520 (4287027) | 4287027..4287838 | + | 812 | Protein_4029 | IS3 family transposase | - |
| CCO42_RS20525 (4288241) | 4288241..4288327 | + | 87 | Protein_4030 | porin family protein | - |
| CCO42_RS20530 (4288418) | 4288418..4289170 | + | 753 | WP_000842426.1 | non-specific acid phosphatase | - |
| CCO42_RS20535 (4289418) | 4289418..4289909 | - | 492 | WP_023255089.1 | GNAT family N-acetyltransferase | Toxin |
| CCO42_RS20540 (4289906) | 4289906..4290199 | - | 294 | WP_001110453.1 | DUF1778 domain-containing protein | Antitoxin |
| CCO42_RS20545 (4290517) | 4290517..4290738 | + | 222 | WP_031612896.1 | hypothetical protein | - |
| CCO42_RS20550 (4291002) | 4291002..4291877 | + | 876 | WP_023195838.1 | AraC family transcriptional regulator | - |
| CCO42_RS20555 (4291874) | 4291874..4292161 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| CCO42_RS23120 (4292154) | 4292154..4292336 | - | 183 | WP_001727659.1 | ATP-binding cassette domain-containing protein | - |
| CCO42_RS23125 (4292356) | 4292356..4292455 | + | 100 | Protein_4038 | hypothetical protein | - |
| CCO42_RS23130 (4292565) | 4292565..4292699 | + | 135 | Protein_4039 | hypothetical protein | - |
| CCO42_RS20565 (4292994) | 4292994..4293899 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4278004..4292336 | 14332 | |
| - | flank | IS/Tn | - | - | 4287027..4287689 | 662 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17633.45 Da Isoelectric Point: 7.7297
>T202924 WP_023255089.1 NZ_CP075112:c4289909-4289418 [Salmonella enterica subsp. enterica serovar Corvallis]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T202924 NZ_CP099752:1920406-1920684 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10948.57 Da Isoelectric Point: 9.8590
>AT202924 WP_001110453.1 NZ_CP075112:c4290199-4289906 [Salmonella enterica subsp. enterica serovar Corvallis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT202924 NZ_CP099752:1920143-1920403 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I1HVL4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V4SIN7 |