Detailed information of TA system TA202923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DinJ
• Location: 4152681..4153197
• Replicon: chromosome
• Accession: NZ_CP075112
• Organism: Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5I6CHB9
• Locus tag: CCO42_RS19835
• Protein ID: WP_000220581.1
• Coordinates: 4152681..4152965 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CCO42_RS19840
• Protein ID: WP_023217946.1
• Coordinates: 4152955..4153197 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO42_RS19820 (4147797)	4147797..4149449	+	1653	WP_063808990.1	alpha,alpha-phosphotrehalase	-
CCO42_RS19825 (4149858)	4149858..4151996	+	2139	WP_023238045.1	anaerobic ribonucleoside-triphosphate reductase	-
CCO42_RS19830 (4152213)	4152213..4152677	+	465	WP_001009175.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
CCO42_RS19835 (4152681)	4152681..4152965	-	285	WP_000220581.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCO42_RS19840 (4152955)	4152955..4153197	-	243	WP_023217946.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CCO42_RS19845 (4153275)	4153275..4155188	-	1914	WP_139769940.1	BglG family transcription antiterminator	-
CCO42_RS19850 (4155205)	4155205..4155945	-	741	WP_039517299.1	KDGP aldolase family protein	-
CCO42_RS19855 (4155942)	4155942..4157060	-	1119	WP_094963992.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
CCO42_RS19860 (4157044)	4157044..4158177	-	1134	WP_063808993.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10868.70 Da
• Isoelectric Point: 10.0482

>T202923 WP_000220581.1 NZ_CP075112:c4152965-4152681 [Salmonella enterica subsp. enterica serovar Corvallis]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T202923 NZ_CP099752:1749574-1750116 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8975.37 Da
• Isoelectric Point: 5.0651

>AT202923 WP_023217946.1 NZ_CP075112:c4153197-4152955 [Salmonella enterica subsp. enterica serovar Corvallis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT202923 NZ_CP099752:1749279-1749590 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Toxin

• AlphaFold DB: A0A5I6CHB9