Detailed information of TA system TA202922

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yeeU/CbtA-CbeA
• Location: 4086643..4087331
• Replicon: chromosome
• Accession: NZ_CP075112
• Organism: Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: V7IRX8
• Locus tag: CCO42_RS19530
• Protein ID: WP_020898322.1
• Coordinates: 4086643..4086987 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: V7IUU6
• Locus tag: CCO42_RS19535
• Protein ID: WP_020898321.1
• Coordinates: 4087002..4087331 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO42_RS23105 (4084009)	4084009..4084283	-	275	Protein_3830	Arm DNA-binding domain-containing protein	-
CCO42_RS19510 (4084718)	4084718..4085026	-	309	WP_020898325.1	CcdB family protein	-
CCO42_RS19515 (4085029)	4085029..4085268	-	240	WP_000016244.1	type II toxin-antitoxin system CcdA family antitoxin	-
CCO42_RS19520 (4085381)	4085381..4085629	-	249	WP_020898324.1	ribbon-helix-helix protein, CopG family	-
CCO42_RS19525 (4085694)	4085694..4086527	-	834	WP_063808974.1	DUF4942 domain-containing protein	-
CCO42_RS19530 (4086643)	4086643..4086987	-	345	WP_020898322.1	TA system toxin CbtA family protein	Toxin
CCO42_RS19535 (4087002)	4087002..4087331	-	330	WP_020898321.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CCO42_RS19540 (4087394)	4087394..4087894	-	501	WP_020898320.1	DNA repair protein RadC	-
CCO42_RS19545 (4087907)	4087907..4088725	-	819	WP_020898319.1	DUF932 domain-containing protein	-
CCO42_RS19550 (4088827)	4088827..4089072	-	246	WP_020898318.1	DUF905 domain-containing protein	-
CCO42_RS19555 (4089161)	4089161..4089607	-	447	WP_020898317.1	IrmA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4070225..4110534	40309

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (13-110)

Antitoxin

• Antitoxin CbeA (10-108)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13067.94 Da
• Isoelectric Point: 8.8987

>T202922 WP_020898322.1 NZ_CP075112:c4086987-4086643 [Salmonella enterica subsp. enterica serovar Corvallis]
MQNVLSLSSPAATPSRLSPVEAWRKLLSYLLQRHYGLELNDTPFCDDSVIQEHINAGVTLADAVNFLVEKYELVRIDRKG
FSWQEQSPYLRAVDILRARQATGLLRRQRYLAAH

Nucleotide

• Length: 345 bp

>T202922 NZ_CP099752:1715602-1715820 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12095.68 Da
• Isoelectric Point: 6.4672

>AT202922 WP_020898321.1 NZ_CP075112:c4087331-4087002 [Salmonella enterica subsp. enterica serovar Corvallis]
MPQNQPSVPVWGLRSDITPSFGARLVQEGCRLHFLADRASLCGNFTPEQLQTLEVTFPQFVKQLESVLKSGALDPRQPHR
HSITLNGLTCEADTNGSHGYVYLTIYPAE

Nucleotide

• Length: 330 bp

>AT202922 NZ_CP099752:1715202-1715576 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGATGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: V7IRX8

Antitoxin

• AlphaFold DB: V7IUU6