Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4084718..4085268 Replicon chromosome
Accession NZ_CP075112
Organism Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)


Gene name ccdB Uniprot ID V7IUU9
Locus tag CCO42_RS19510 Protein ID WP_020898325.1
Coordinates 4084718..4085026 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag CCO42_RS19515 Protein ID WP_000016244.1
Coordinates 4085029..4085268 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO42_RS19500 (4080753) 4080753..4083640 - 2888 Protein_3829 AAA domain-containing protein -
CCO42_RS23105 (4084009) 4084009..4084283 - 275 Protein_3830 Arm DNA-binding domain-containing protein -
CCO42_RS19510 (4084718) 4084718..4085026 - 309 WP_020898325.1 CcdB family protein Toxin
CCO42_RS19515 (4085029) 4085029..4085268 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CCO42_RS19520 (4085381) 4085381..4085629 - 249 WP_020898324.1 ribbon-helix-helix protein, CopG family -
CCO42_RS19525 (4085694) 4085694..4086527 - 834 WP_063808974.1 DUF4942 domain-containing protein -
CCO42_RS19530 (4086643) 4086643..4086987 - 345 WP_020898322.1 TA system toxin CbtA family protein -
CCO42_RS19535 (4087002) 4087002..4087331 - 330 WP_020898321.1 type IV toxin-antitoxin system YeeU family antitoxin -
CCO42_RS19540 (4087394) 4087394..4087894 - 501 WP_020898320.1 DNA repair protein RadC -
CCO42_RS19545 (4087907) 4087907..4088725 - 819 WP_020898319.1 DUF932 domain-containing protein -
CCO42_RS19550 (4088827) 4088827..4089072 - 246 WP_020898318.1 DUF905 domain-containing protein -
CCO42_RS19555 (4089161) 4089161..4089607 - 447 WP_020898317.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4070225..4110534 40309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11835.63 Da        Isoelectric Point: 6.7228

>T202921 WP_020898325.1 NZ_CP075112:c4085026-4084718 [Salmonella enterica subsp. enterica serovar Corvallis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNSVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T202921 NZ_CP099752:918472-918579 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT202921 WP_000016244.1 NZ_CP075112:c4085268-4085029 [Salmonella enterica subsp. enterica serovar Corvallis]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT202921 NZ_CP099752:c918422-918359 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7IUU9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References