Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3420467..3421087 Replicon chromosome
Accession NZ_CP075112
Organism Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CCO42_RS16435 Protein ID WP_001280991.1
Coordinates 3420869..3421087 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CCO42_RS16430 Protein ID WP_000344807.1
Coordinates 3420467..3420841 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO42_RS16420 (3415606) 3415606..3416799 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CCO42_RS16425 (3416822) 3416822..3419971 + 3150 WP_094963759.1 efflux RND transporter permease AcrB -
CCO42_RS16430 (3420467) 3420467..3420841 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CCO42_RS16435 (3420869) 3420869..3421087 + 219 WP_001280991.1 HHA domain-containing protein Toxin
CCO42_RS16440 (3421266) 3421266..3421817 + 552 WP_001278793.1 maltose O-acetyltransferase -
CCO42_RS16445 (3421934) 3421934..3422404 + 471 WP_000136183.1 YlaC family protein -
CCO42_RS16450 (3422460) 3422460..3422600 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CCO42_RS16455 (3422606) 3422606..3422866 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CCO42_RS16460 (3423091) 3423091..3424641 + 1551 WP_000213145.1 EAL domain-containing protein -
CCO42_RS16470 (3424872) 3424872..3425261 + 390 WP_000961285.1 MGMT family protein -
CCO42_RS16475 (3425294) 3425294..3425863 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202920 WP_001280991.1 NZ_CP075112:3420869-3421087 [Salmonella enterica subsp. enterica serovar Corvallis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202920 NZ_CP099752:917937-918044 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202920 WP_000344807.1 NZ_CP075112:3420467-3420841 [Salmonella enterica subsp. enterica serovar Corvallis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202920 NZ_CP099752:c917890-917824 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References