202919

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2390048..2390570 Replicon chromosome
Accession NZ_CP075112
Organism Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag CCO42_RS11375 Protein ID WP_000221343.1
Coordinates 2390286..2390570 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag CCO42_RS11370 Protein ID WP_000885426.1
Coordinates 2390048..2390296 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO42_RS11350 (2385619) 2385619..2387130 - 1512 WP_023231843.1 FGGY family carbohydrate kinase -
CCO42_RS11355 (2387208) 2387208..2388599 - 1392 WP_023218026.1 PTS galactitol transporter subunit IIC -
CCO42_RS11360 (2388611) 2388611..2388892 - 282 WP_023218025.1 PTS sugar transporter subunit IIB -
CCO42_RS11365 (2388952) 2388952..2389416 - 465 WP_072275481.1 PTS sugar transporter subunit IIA -
CCO42_RS11370 (2390048) 2390048..2390296 + 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CCO42_RS11375 (2390286) 2390286..2390570 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCO42_RS11380 (2390741) 2390741..2391130 + 390 WP_023206403.1 RidA family protein -
CCO42_RS11385 (2391188) 2391188..2392261 - 1074 WP_063809231.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
CCO42_RS11390 (2392454) 2392454..2392942 - 489 WP_001293635.1 MarR family winged helix-turn-helix transcriptional regulator -
CCO42_RS11395 (2392987) 2392987..2394495 + 1509 WP_063809230.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2375013..2397352 22339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T202919 WP_000221343.1 NZ_CP075112:2390286-2390570 [Salmonella enterica subsp. enterica serovar Corvallis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T202919 NZ_CP099752:917402-917509 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT202919 WP_000885426.1 NZ_CP075112:2390048-2390296 [Salmonella enterica subsp. enterica serovar Corvallis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT202919 NZ_CP099752:c917355-917289 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References