Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1021267..1022081 | Replicon | chromosome |
| Accession | NZ_CP075112 | ||
| Organism | Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | - |
| Locus tag | CCO42_RS04855 | Protein ID | WP_094963860.1 |
| Coordinates | 1021267..1021794 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | CCO42_RS04860 | Protein ID | WP_000855694.1 |
| Coordinates | 1021791..1022081 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCO42_RS04825 (1017468) | 1017468..1017889 | + | 422 | Protein_947 | cytoplasmic protein | - |
| CCO42_RS04830 (1018057) | 1018057..1018296 | + | 240 | Protein_948 | hypothetical protein | - |
| CCO42_RS04835 (1018453) | 1018453..1019121 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| CCO42_RS04840 (1019148) | 1019148..1019642 | + | 495 | WP_000424947.1 | hypothetical protein | - |
| CCO42_RS04845 (1019887) | 1019887..1020543 | - | 657 | WP_000420451.1 | protein-serine/threonine phosphatase | - |
| CCO42_RS04850 (1020770) | 1020770..1021194 | + | 425 | Protein_952 | transposase | - |
| CCO42_RS04855 (1021267) | 1021267..1021794 | - | 528 | WP_094963860.1 | GNAT family N-acetyltransferase | Toxin |
| CCO42_RS04860 (1021791) | 1021791..1022081 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| CCO42_RS04865 (1022351) | 1022351..1022551 | - | 201 | Protein_955 | transposase | - |
| CCO42_RS04870 (1022792) | 1022792..1023118 | + | 327 | WP_080231986.1 | hypothetical protein | - |
| CCO42_RS04875 (1023390) | 1023390..1023737 | - | 348 | WP_001555786.1 | DUF1493 family protein | - |
| CCO42_RS04880 (1023722) | 1023722..1024171 | - | 450 | WP_000381616.1 | hypothetical protein | - |
| CCO42_RS04885 (1024590) | 1024590..1025033 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| CCO42_RS04890 (1025490) | 1025490..1026140 | + | 651 | WP_074182111.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1019887..1031453 | 11566 | |
| - | flank | IS/Tn | - | - | 1021018..1021194 | 176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 18984.80 Da Isoelectric Point: 9.3905
>T202910 WP_094963860.1 NZ_CP075112:c1021794-1021267 [Salmonella enterica subsp. enterica serovar Corvallis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGIALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGIALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T202910 NZ_CP099749:c55509-55186 [Klebsiella pneumoniae]
ATGAACTATCTGGAGTTTGTTGAAACCAGCGCTTTCAGTGGACTGCGTAAGGAACTCATGGATGATGATGAATTCCGCGA
ACTGCAGACCTATTTACTGGAAGCCCATGATCGGGGTGACACCATCAGTCATACCGGTGGATGCAGGAAGATTCGCTGGG
GTCGCCCGGGGATGGGTAAACGAGGTGGCGTCAGGGTGATTTACTACGTTCGTCTTGCCAGCGGCAGACTGTATCTGCTG
CTGATATACCCGAAGAATGCGAAAGATGAGCTCAGCGAGAAAGAAAAAGCCGTTATGAAGGCATTAACACAGCAGCTGAA
GTAA
ATGAACTATCTGGAGTTTGTTGAAACCAGCGCTTTCAGTGGACTGCGTAAGGAACTCATGGATGATGATGAATTCCGCGA
ACTGCAGACCTATTTACTGGAAGCCCATGATCGGGGTGACACCATCAGTCATACCGGTGGATGCAGGAAGATTCGCTGGG
GTCGCCCGGGGATGGGTAAACGAGGTGGCGTCAGGGTGATTTACTACGTTCGTCTTGCCAGCGGCAGACTGTATCTGCTG
CTGATATACCCGAAGAATGCGAAAGATGAGCTCAGCGAGAAAGAAAAAGCCGTTATGAAGGCATTAACACAGCAGCTGAA
GTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT202910 WP_000855694.1 NZ_CP075112:c1022081-1021791 [Salmonella enterica subsp. enterica serovar Corvallis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT202910 NZ_CP099749:c55137-54835 [Klebsiella pneumoniae]
ATGGAAAAGAAACTTTTTGATGCCCTGATCAGCAGCATGGAGGAAATGGTGGCCATTGAAAATGGCCAGATCCAGCCCGC
TGCAGAACAGGTTCACCGCCATACACTGCCGGATGTGAAAGCCATTCGTAAACATGCCGGCATGAAACAGGCTGAATTTG
CAGAAGTGGTGGGGGCCAGCGTTGACCTTGTTCGCAGCTGGGAACAGCAACGGCGTGTTCCGTCGGGTATTGCGCTGAAA
ATGCTCTGCCTCATCGAGCGTGAGCCTGCACTGATTAATACGTTGCGTGGTATTCACGTCTGA
ATGGAAAAGAAACTTTTTGATGCCCTGATCAGCAGCATGGAGGAAATGGTGGCCATTGAAAATGGCCAGATCCAGCCCGC
TGCAGAACAGGTTCACCGCCATACACTGCCGGATGTGAAAGCCATTCGTAAACATGCCGGCATGAAACAGGCTGAATTTG
CAGAAGTGGTGGGGGCCAGCGTTGACCTTGTTCGCAGCTGGGAACAGCAACGGCGTGTTCCGTCGGGTATTGCGCTGAAA
ATGCTCTGCCTCATCGAGCGTGAGCCTGCACTGATTAATACGTTGCGTGGTATTCACGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|