Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 856199..856859 Replicon chromosome
Accession NZ_CP075112
Organism Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag CCO42_RS04120 Protein ID WP_000244756.1
Coordinates 856446..856859 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag CCO42_RS04115 Protein ID WP_000351186.1
Coordinates 856199..856465 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO42_RS04095 (852127) 852127..853560 - 1434 WP_063808818.1 6-phospho-beta-glucosidase BglA -
CCO42_RS04100 (853719) 853719..854030 + 312 WP_001727953.1 N(4)-acetylcytidine aminohydrolase -
CCO42_RS04105 (854194) 854194..854853 + 660 WP_000250289.1 hemolysin III family protein -
CCO42_RS04110 (854969) 854969..855949 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
CCO42_RS04115 (856199) 856199..856465 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
CCO42_RS04120 (856446) 856446..856859 + 414 WP_000244756.1 protein YgfX Toxin
CCO42_RS04125 (856912) 856912..857433 - 522 WP_001055885.1 flavodoxin FldB -
CCO42_RS04130 (857546) 857546..858442 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
CCO42_RS04135 (858466) 858466..859179 + 714 WP_063808817.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CCO42_RS04140 (859185) 859185..860918 + 1734 WP_063808816.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T202909 WP_000244756.1 NZ_CP075112:856446-856859 [Salmonella enterica subsp. enterica serovar Corvallis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T202909 NZ_CP099749:40537-40953 [Klebsiella pneumoniae]
GTGAACAGGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
TGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGGTTTCGGCCATTACCTACTCCGAGATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCGCCCCGACATGTGCAGCTGGTTGACGCGTTCTGCACCCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATAAAGGTGGCGCTGCGCCTCGCCGGGACGCCGATAGGCGCGAACGACACGGCGATCGC
CGGGCACGCCATCGCCGCCGGCGCGGTGCTGGTGACGAATAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGGTGCTCG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202909 WP_000351186.1 NZ_CP075112:856199-856465 [Salmonella enterica subsp. enterica serovar Corvallis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202909 NZ_CP099749:40310-40540 [Klebsiella pneumoniae]
ATGAGAACCGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCATTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGGGTTAATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References