Detailed information of TA system TA202908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 776538..777316
• Replicon: chromosome
• Accession: NZ_CP075112
• Organism: Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: CCO42_RS03720
• Protein ID: WP_080178391.1
• Coordinates: 776828..777316 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: CCO42_RS03715
• Protein ID: WP_080178390.1
• Coordinates: 776538..776831 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO42_RS03675 (771747)	771747..771932	-	186	WP_076933227.1	DUF3289 family protein	-
CCO42_RS03680 (772307)	772307..772693	-	387	WP_254879427.1	hypothetical protein	-
CCO42_RS03685 (773096)	773096..773374	-	279	WP_076933226.1	bacteriocin immunity protein	-
CCO42_RS03690 (773617)	773617..773883	-	267	WP_000768133.1	bacteriocin immunity protein	-
CCO42_RS03695 (773880)	773880..774196	-	317	Protein_726	PAAR domain-containing protein	-
CCO42_RS22920 (774632)	774632..774742	-	111	WP_254879428.1	DUF1851 domain-containing protein	-
CCO42_RS03705 (775293)	775293..775433	-	141	Protein_728	type VI secretion system tube protein Hcp	-
CCO42_RS22925 (775488)	775488..776127	-	640	Protein_729	integrase arm-type DNA-binding domain-containing protein	-
CCO42_RS03715 (776538)	776538..776831	+	294	WP_080178390.1	DUF1778 domain-containing protein	Antitoxin
CCO42_RS03720 (776828)	776828..777316	+	489	WP_080178391.1	GNAT family N-acetyltransferase	Toxin
CCO42_RS03725 (777374)	777374..779299	-	1926	WP_076933221.1	hypothetical protein	-
CCO42_RS03730 (779309)	779309..781282	-	1974	WP_076933220.1	hypothetical protein	-
CCO42_RS03735 (781279)	781279..781932	-	654	WP_076933219.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	770393..783135	12742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-95)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17573.59 Da
• Isoelectric Point: 8.1467

>T202908 WP_080178391.1 NZ_CP075112:776828-777316 [Salmonella enterica subsp. enterica serovar Corvallis]
MISAPEPLHTGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLGDLVG
LV

Nucleotide

• Length: 489 bp

>T202908 NZ_CP099748:c5273398-5273015 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10913.53 Da
• Isoelectric Point: 8.6373

>AT202908 WP_080178390.1 NZ_CP075112:776538-776831 [Salmonella enterica subsp. enterica serovar Corvallis]
MPAANSMAMKRETLNLRIKPTERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQHIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT202908 NZ_CP099748:c5273640-5273398 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA