Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 214829..215589 Replicon chromosome
Accession NZ_CP075112
Organism Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag CCO42_RS00995 Protein ID WP_000533909.1
Coordinates 215104..215589 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag CCO42_RS00990 Protein ID WP_094963951.1
Coordinates 214829..215116 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO42_RS00975 (210162) 210162..211529 - 1368 WP_031605989.1 DUF4147 domain-containing protein -
CCO42_RS00980 (211589) 211589..212905 - 1317 WP_031605990.1 MFS transporter -
CCO42_RS00985 (213038) 213038..214330 - 1293 WP_000097706.1 phosphopyruvate hydratase -
CCO42_RS00990 (214829) 214829..215116 + 288 WP_094963951.1 DUF1778 domain-containing protein Antitoxin
CCO42_RS00995 (215104) 215104..215589 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
CCO42_RS01000 (215961) 215961..216500 - 540 WP_094963952.1 copper-binding periplasmic metallochaperone CueP -
CCO42_RS01005 (216674) 216674..216886 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CCO42_RS01010 (217174) 217174..217464 - 291 WP_000455790.1 HTH-type transcriptional regulator -
CCO42_RS01015 (217903) 217903..218613 + 711 WP_000190524.1 DUF3053 domain-containing protein -
CCO42_RS01020 (218663) 218663..219637 - 975 WP_000804681.1 glyoxylate/hydroxypyruvate reductase GhrB -
CCO42_RS01025 (219867) 219867..220529 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 205720..215589 9869


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T202907 WP_000533909.1 NZ_CP075112:215104-215589 [Salmonella enterica subsp. enterica serovar Corvallis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202907 NZ_CP099748:c4799075-4798791 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTATGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.52 Da        Isoelectric Point: 4.5256

>AT202907 WP_094963951.1 NZ_CP075112:214829-215116 [Salmonella enterica subsp. enterica serovar Corvallis]
MLYNGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202907 NZ_CP099748:c4799307-4799065 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure

References