Detailed information of TA system TA202907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 214829..215589
• Replicon: chromosome
• Accession: NZ_CP075112
• Organism: Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: Q57IH1
• Locus tag: CCO42_RS00995
• Protein ID: WP_000533909.1
• Coordinates: 215104..215589 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: CCO42_RS00990
• Protein ID: WP_094963951.1
• Coordinates: 214829..215116 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO42_RS00975 (210162)	210162..211529	-	1368	WP_031605989.1	DUF4147 domain-containing protein	-
CCO42_RS00980 (211589)	211589..212905	-	1317	WP_031605990.1	MFS transporter	-
CCO42_RS00985 (213038)	213038..214330	-	1293	WP_000097706.1	phosphopyruvate hydratase	-
CCO42_RS00990 (214829)	214829..215116	+	288	WP_094963951.1	DUF1778 domain-containing protein	Antitoxin
CCO42_RS00995 (215104)	215104..215589	+	486	WP_000533909.1	GNAT family N-acetyltransferase	Toxin
CCO42_RS01000 (215961)	215961..216500	-	540	WP_094963952.1	copper-binding periplasmic metallochaperone CueP	-
CCO42_RS01005 (216674)	216674..216886	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
CCO42_RS01010 (217174)	217174..217464	-	291	WP_000455790.1	HTH-type transcriptional regulator	-
CCO42_RS01015 (217903)	217903..218613	+	711	WP_000190524.1	DUF3053 domain-containing protein	-
CCO42_RS01020 (218663)	218663..219637	-	975	WP_000804681.1	glyoxylate/hydroxypyruvate reductase GhrB	-
CCO42_RS01025 (219867)	219867..220529	-	663	WP_000747548.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	205720..215589	9869

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (31-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (13-89)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17703.41 Da
• Isoelectric Point: 9.8719

>T202907 WP_000533909.1 NZ_CP075112:215104-215589 [Salmonella enterica subsp. enterica serovar Corvallis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T202907 NZ_CP099748:c4799075-4798791 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTATGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10950.52 Da
• Isoelectric Point: 4.5256

>AT202907 WP_094963951.1 NZ_CP075112:214829-215116 [Salmonella enterica subsp. enterica serovar Corvallis]
MLYNGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Nucleotide

• Length: 288 bp

>AT202907 NZ_CP099748:c4799307-4799065 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• PDB: 7F36
• PDB: 7AK8
• PDB: 5FVJ