Detailed information of TA system TA202906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 75579..76615
• Replicon: plasmid pCFSAN060804
• Accession: NZ_CP075111
• Organism: Salmonella enterica strain CFSAN060804

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: CIC27_RS23910
• Protein ID: WP_031233190.1
• Coordinates: 76040..76615 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A2A6D4K4
• Locus tag: CIC27_RS23905
• Protein ID: WP_023972447.1
• Coordinates: 75579..76040 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC27_RS23875 (71271)	71271..72149	+	879	WP_023972454.1	restriction endonuclease	-
CIC27_RS23880 (72190)	72190..72618	-	429	WP_023972453.1	PIN domain-containing protein	-
CIC27_RS23885 (72615)	72615..72845	-	231	WP_023972452.1	type II toxin-antitoxin system VapB family antitoxin	-
CIC27_RS23890 (73420)	73420..73734	+	315	WP_139148288.1	hypothetical protein	-
CIC27_RS23895 (73778)	73778..74485	+	708	WP_023972450.1	hypothetical protein	-
CIC27_RS23900 (74482)	74482..75258	+	777	Protein_67	site-specific integrase	-
CIC27_RS24450 (75274)	75274..75369	+	96	Protein_68	malate dehydrogenase	-
CIC27_RS23905 (75579)	75579..76040	+	462	WP_023972447.1	helix-turn-helix domain-containing protein	Antitoxin
CIC27_RS23910 (76040)	76040..76615	+	576	WP_031233190.1	PIN domain-containing protein	Toxin
CIC27_RS23915 (77296)	77296..78162	+	867	WP_023972445.1	AAA family ATPase	-
CIC27_RS23920 (78162)	78162..79193	+	1032	WP_023972444.1	ParB/RepB/Spo0J family partition protein	-
CIC27_RS23925 (79193)	79193..79630	+	438	WP_000843283.1	hypothetical protein	-
CIC27_RS23930 (79627)	79627..79950	+	324	WP_023972443.1	hypothetical protein	-
CIC27_RS23935 (80000)	80000..81373	+	1374	WP_023972442.1	RES family NAD+ phosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..101510	101510

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21416.70 Da
• Isoelectric Point: 4.7272

>T202906 WP_031233190.1 NZ_CP075111:76040-76615 [Salmonella enterica]
MNHTPYPVVLDACVLYPSFLRDLLIRLGLTGLYQPKWSASIENEWQRNLLANRTDLTEEQIKRTATLMNKAVPDALVTGF
EPLIDSIDLPDVDDRHVAAAAVRSNAEIIVTLNLKDFPAPALDAFGIEALHPDDFVMDLFDLNRALVLSAVTTQRSSLRK
PPVSVDEYLEALLRQGMAQTVKELSKYRMLI

Nucleotide

• Length: 576 bp

>T202906 NZ_CP099748:c4707361-4707020 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACGCCTCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGAACTGGTTCGTATTGATCGTAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGGCAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACAGTGA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 16936.43 Da
• Isoelectric Point: 5.5842

>AT202906 WP_023972447.1 NZ_CP075111:75579-76040 [Salmonella enterica]
MTNSILDSLSLPAKGEIEAAVRGQRELAAYLSTKMETQKISIQDADNVTHQIELPTSSLTLLMSILGELALGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEEGKLPFHKTGRHRRVLFADLMKYKDQRDSDSNIAMQELADLSQELGLY

Nucleotide

• Length: 462 bp

>AT202906 NZ_CP099748:c4707723-4707382 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGGCTGAATCGTAATGTGACGCCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGTTGACCGGGCCAGCATTACCGGTGACTTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CATTTACCCCACTCAACGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A6D4K4