Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 72190..72845 | Replicon | plasmid pCFSAN060804 |
| Accession | NZ_CP075111 | ||
| Organism | Salmonella enterica strain CFSAN060804 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A2A6D4W4 |
| Locus tag | CIC27_RS23880 | Protein ID | WP_023972453.1 |
| Coordinates | 72190..72618 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A2A6D545 |
| Locus tag | CIC27_RS23885 | Protein ID | WP_023972452.1 |
| Coordinates | 72615..72845 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CIC27_RS23840 (67464) | 67464..67832 | - | 369 | Protein_55 | DUF302 domain-containing protein | - |
| CIC27_RS23845 (68046) | 68046..68288 | + | 243 | WP_023972461.1 | YjhX family toxin | - |
| CIC27_RS23850 (68299) | 68299..68846 | + | 548 | Protein_57 | N-acetyltransferase | - |
| CIC27_RS23855 (68932) | 68932..69195 | - | 264 | WP_023972459.1 | hypothetical protein | - |
| CIC27_RS23860 (69192) | 69192..69482 | - | 291 | WP_023972458.1 | hypothetical protein | - |
| CIC27_RS23865 (69507) | 69507..70019 | - | 513 | WP_023972457.1 | hypothetical protein | - |
| CIC27_RS23870 (70396) | 70396..71010 | - | 615 | WP_023972455.1 | DNA-binding protein | - |
| CIC27_RS23875 (71271) | 71271..72149 | + | 879 | WP_023972454.1 | restriction endonuclease | - |
| CIC27_RS23880 (72190) | 72190..72618 | - | 429 | WP_023972453.1 | PIN domain-containing protein | Toxin |
| CIC27_RS23885 (72615) | 72615..72845 | - | 231 | WP_023972452.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| CIC27_RS23890 (73420) | 73420..73734 | + | 315 | WP_139148288.1 | hypothetical protein | - |
| CIC27_RS23895 (73778) | 73778..74485 | + | 708 | WP_023972450.1 | hypothetical protein | - |
| CIC27_RS23900 (74482) | 74482..75258 | + | 777 | Protein_67 | site-specific integrase | - |
| CIC27_RS24450 (75274) | 75274..75369 | + | 96 | Protein_68 | malate dehydrogenase | - |
| CIC27_RS23905 (75579) | 75579..76040 | + | 462 | WP_023972447.1 | helix-turn-helix domain-containing protein | - |
| CIC27_RS23910 (76040) | 76040..76615 | + | 576 | WP_031233190.1 | PIN domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..101510 | 101510 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15583.12 Da Isoelectric Point: 9.9442
>T202905 WP_023972453.1 NZ_CP075111:c72618-72190 [Salmonella enterica]
MKQPRTKTYMLDTNICSFIMREQPEKVLKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHAQLVDAFCARLDTILP
WDKAAVDATTDIKAALAAAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLKLEDWVK
MKQPRTKTYMLDTNICSFIMREQPEKVLKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHAQLVDAFCARLDTILP
WDKAAVDATTDIKAALAAAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLKLEDWVK
Download Length: 429 bp
>T202905 NZ_CP099748:c4672042-4671509 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8889.94 Da Isoelectric Point: 4.3331
>AT202905 WP_023972452.1 NZ_CP075111:c72845-72615 [Salmonella enterica]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWESFFREEKADADFMAEREDVVSDEGRFEL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWESFFREEKADADFMAEREDVVSDEGRFEL
Download Length: 231 bp
>AT202905 NZ_CP099748:c4672319-4672053 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAGTCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAGTCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A6D4W4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A6D545 |