202902

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4241993..4242774 Replicon chromosome
Accession NZ_CP075110
Organism Salmonella enterica strain CFSAN060804

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3V8KWJ7
Locus tag CIC27_RS20875 Protein ID WP_001609688.1
Coordinates 4241993..4242484 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag CIC27_RS20880 Protein ID WP_001110453.1
Coordinates 4242481..4242774 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC27_RS20850 (4237129) 4237129..4239567 - 2439 WP_001014136.1 F4 (K88) fimbrial usher FaeD -
CIC27_RS20855 (4239577) 4239577..4240116 - 540 WP_000721295.1 type 1 fimbrial protein -
CIC27_RS20860 (4240151) 4240151..4240435 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
CIC27_RS20865 (4241028) 4241028..4241255 + 228 WP_001112992.1 hypothetical protein -
CIC27_RS20870 (4241530) 4241530..4241778 - 249 Protein_4116 IS481 family transposase -
CIC27_RS20875 (4241993) 4241993..4242484 - 492 WP_001609688.1 GNAT family N-acetyltransferase Toxin
CIC27_RS20880 (4242481) 4242481..4242774 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
CIC27_RS24380 (4243092) 4243092..4243314 + 223 Protein_4119 hypothetical protein -
CIC27_RS20885 (4243578) 4243578..4244453 + 876 WP_000921676.1 AraC family transcriptional regulator -
CIC27_RS20890 (4244450) 4244450..4244737 + 288 WP_001269916.1 transcriptional regulator RtsB -
CIC27_RS24385 (4244730) 4244730..4244912 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
CIC27_RS24390 (4244932) 4244932..4245031 + 100 Protein_4123 hypothetical protein -
CIC27_RS24395 (4245141) 4245141..4245275 + 135 Protein_4124 hypothetical protein -
CIC27_RS20900 (4245570) 4245570..4246475 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeF / faeE / faeD / faeC 4235788..4244912 9124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17664.46 Da        Isoelectric Point: 7.2655

>T202902 WP_001609688.1 NZ_CP075110:c4242484-4241993 [Salmonella enterica]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVEETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T202902 NZ_CP099748:c2638560-2637238 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGAGAGCAGATGTTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT202902 WP_001110453.1 NZ_CP075110:c4242774-4242481 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202902 NZ_CP099748:c2638826-2638560 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8KWJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References