Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4104097..4104613 Replicon chromosome
Accession NZ_CP075110
Organism Salmonella enterica strain CFSAN060804

Toxin (Protein)


Gene name relE Uniprot ID A0A5J2LRU5
Locus tag CIC27_RS20160 Protein ID WP_001609934.1
Coordinates 4104097..4104381 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A6DDA6
Locus tag CIC27_RS20165 Protein ID WP_023972421.1
Coordinates 4104371..4104613 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC27_RS20145 (4099213) 4099213..4100865 + 1653 WP_023212814.1 alpha,alpha-phosphotrehalase -
CIC27_RS20150 (4101274) 4101274..4103412 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
CIC27_RS20155 (4103629) 4103629..4104093 + 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CIC27_RS20160 (4104097) 4104097..4104381 - 285 WP_001609934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CIC27_RS20165 (4104371) 4104371..4104613 - 243 WP_023972421.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CIC27_RS20170 (4104691) 4104691..4106604 - 1914 WP_001609931.1 BglG family transcription antiterminator -
CIC27_RS20175 (4106621) 4106621..4107361 - 741 WP_023229489.1 KDGP aldolase family protein -
CIC27_RS20180 (4107358) 4107358..4108476 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CIC27_RS20185 (4108460) 4108460..4109593 - 1134 WP_001609909.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10859.66 Da        Isoelectric Point: 9.3941

>T202901 WP_001609934.1 NZ_CP075110:c4104381-4104097 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSACLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202901 NZ_CP099748:1877635-1877737 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8993.40 Da        Isoelectric Point: 5.0651

>AT202901 WP_023972421.1 NZ_CP075110:c4104613-4104371 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPMKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202901 NZ_CP099748:c1877744-1877599 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J2LRU5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A6DDA6

References