Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4063480..4064030 Replicon chromosome
Accession NZ_CP075110
Organism Salmonella enterica strain CFSAN060804

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag CIC27_RS19955 Protein ID WP_001199743.1
Coordinates 4063480..4063788 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag CIC27_RS19960 Protein ID WP_000016243.1
Coordinates 4063791..4064030 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC27_RS19945 (4058880) 4058880..4062395 - 3516 WP_000342548.1 AAA domain-containing protein -
CIC27_RS24365 (4062757) 4062757..4063058 - 302 Protein_3936 Arm DNA-binding domain-containing protein -
CIC27_RS19955 (4063480) 4063480..4063788 - 309 WP_001199743.1 CcdB family protein Toxin
CIC27_RS19960 (4063791) 4063791..4064030 - 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CIC27_RS19965 (4064139) 4064139..4064363 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
CIC27_RS19975 (4065148) 4065148..4066167 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
CIC27_RS19980 (4066195) 4066195..4066725 - 531 WP_023231125.1 gluconokinase -
CIC27_RS19985 (4066942) 4066942..4067973 + 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
CIC27_RS19990 (4067998) 4067998..4068762 + 765 WP_000998688.1 gluconate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T202900 WP_001199743.1 NZ_CP075110:c4063788-4063480 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T202900 NZ_CP099748:799509-799919 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT202900 WP_000016243.1 NZ_CP075110:c4064030-4063791 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp

>AT202900 NZ_CP099748:799262-799528 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References