Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3435468..3436088 Replicon chromosome
Accession NZ_CP075110
Organism Salmonella enterica strain CFSAN060804

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CIC27_RS17075 Protein ID WP_001280991.1
Coordinates 3435870..3436088 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CIC27_RS17070 Protein ID WP_000344807.1
Coordinates 3435468..3435842 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC27_RS17060 (3430607) 3430607..3431800 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CIC27_RS17065 (3431823) 3431823..3434972 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
CIC27_RS17070 (3435468) 3435468..3435842 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CIC27_RS17075 (3435870) 3435870..3436088 + 219 WP_001280991.1 HHA domain-containing protein Toxin
CIC27_RS17080 (3436267) 3436267..3436818 + 552 WP_001278791.1 maltose O-acetyltransferase -
CIC27_RS17085 (3436936) 3436936..3437406 + 471 WP_000136183.1 YlaC family protein -
CIC27_RS17090 (3437462) 3437462..3437602 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CIC27_RS17095 (3437608) 3437608..3437868 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CIC27_RS17100 (3438093) 3438093..3439643 + 1551 WP_023230872.1 EAL domain-containing protein -
CIC27_RS17110 (3439874) 3439874..3440263 + 390 WP_023230873.1 MGMT family protein -
CIC27_RS17115 (3440296) 3440296..3440865 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202899 WP_001280991.1 NZ_CP075110:3435870-3436088 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202899 NZ_CP099748:377927-378274 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGACAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202899 WP_000344807.1 NZ_CP075110:3435468-3435842 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202899 NZ_CP099748:378274-378573 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References