Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2349857..2350379 Replicon chromosome
Accession NZ_CP075110
Organism Salmonella enterica strain CFSAN060804

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag CIC27_RS11415 Protein ID WP_000221344.1
Coordinates 2350095..2350379 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag CIC27_RS11410 Protein ID WP_000885424.1
Coordinates 2349857..2350105 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC27_RS11380 (2345025) 2345025..2345240 + 216 WP_001530185.1 hypothetical protein -
CIC27_RS11385 (2345675) 2345675..2346598 + 924 WP_023972398.1 hypothetical protein -
CIC27_RS11390 (2347013) 2347013..2347588 + 576 Protein_2245 helix-turn-helix domain-containing protein -
CIC27_RS11395 (2347659) 2347659..2348609 - 951 WP_000941990.1 toll/interleukin-1 receptor domain-containing protein -
CIC27_RS11400 (2348773) 2348773..2349105 - 333 WP_000253166.1 DUF1493 family protein -
CIC27_RS11405 (2349099) 2349099..2349557 - 459 WP_000381836.1 hypothetical protein -
CIC27_RS11410 (2349857) 2349857..2350105 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CIC27_RS11415 (2350095) 2350095..2350379 + 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CIC27_RS11420 (2350498) 2350498..2350779 + 282 Protein_2251 RidA family protein -
CIC27_RS11425 (2350831) 2350831..2351910 - 1080 WP_000954705.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
CIC27_RS11430 (2352103) 2352103..2352591 - 489 WP_001293633.1 MarR family winged helix-turn-helix transcriptional regulator -
CIC27_RS11435 (2352636) 2352636..2354144 + 1509 WP_000199421.1 FAD-dependent oxidoreductase -
CIC27_RS11440 (2354134) 2354134..2355375 + 1242 WP_001095723.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2344113..2357001 12888


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T202898 WP_000221344.1 NZ_CP075110:2350095-2350379 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

>T202898 NZ_CP099748:351958-352326 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT202898 WP_000885424.1 NZ_CP075110:2349857-2350105 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT202898 NZ_CP099748:351740-351961 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References