Detailed information of TA system TA202898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2349857..2350379
• Replicon: chromosome
• Accession: NZ_CP075110
• Organism: Salmonella enterica strain CFSAN060804

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A5J1ICX1
• Locus tag: CIC27_RS11415
• Protein ID: WP_000221344.1
• Coordinates: 2350095..2350379 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: CIC27_RS11410
• Protein ID: WP_000885424.1
• Coordinates: 2349857..2350105 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC27_RS11380 (2345025)	2345025..2345240	+	216	WP_001530185.1	hypothetical protein	-
CIC27_RS11385 (2345675)	2345675..2346598	+	924	WP_023972398.1	hypothetical protein	-
CIC27_RS11390 (2347013)	2347013..2347588	+	576	Protein_2245	helix-turn-helix domain-containing protein	-
CIC27_RS11395 (2347659)	2347659..2348609	-	951	WP_000941990.1	toll/interleukin-1 receptor domain-containing protein	-
CIC27_RS11400 (2348773)	2348773..2349105	-	333	WP_000253166.1	DUF1493 family protein	-
CIC27_RS11405 (2349099)	2349099..2349557	-	459	WP_000381836.1	hypothetical protein	-
CIC27_RS11410 (2349857)	2349857..2350105	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CIC27_RS11415 (2350095)	2350095..2350379	+	285	WP_000221344.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CIC27_RS11420 (2350498)	2350498..2350779	+	282	Protein_2251	RidA family protein	-
CIC27_RS11425 (2350831)	2350831..2351910	-	1080	WP_000954705.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
CIC27_RS11430 (2352103)	2352103..2352591	-	489	WP_001293633.1	MarR family winged helix-turn-helix transcriptional regulator	-
CIC27_RS11435 (2352636)	2352636..2354144	+	1509	WP_000199421.1	FAD-dependent oxidoreductase	-
CIC27_RS11440 (2354134)	2354134..2355375	+	1242	WP_001095723.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2344113..2357001	12888

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11015.73 Da
• Isoelectric Point: 10.5388

>T202898 WP_000221344.1 NZ_CP075110:2350095-2350379 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Nucleotide

• Length: 285 bp

>T202898 NZ_CP099748:351958-352326 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT202898 WP_000885424.1 NZ_CP075110:2349857-2350105 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT202898 NZ_CP099748:351740-351961 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A5J1ICX1

Antitoxin

• AlphaFold DB: A0A5I0WPN5