Detailed information of TA system TA202887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 208868..209628
• Replicon: chromosome
• Accession: NZ_CP075110
• Organism: Salmonella enterica strain CFSAN060804

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A0A3V9PR68
• Locus tag: CIC27_RS00990
• Protein ID: WP_000533907.1
• Coordinates: 209143..209628 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: M7RHS4
• Locus tag: CIC27_RS00985
• Protein ID: WP_000965886.1
• Coordinates: 208868..209155 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC27_RS00960 (203957)	203957..204259	+	303	WP_000605592.1	YsaB family lipoprotein	-
CIC27_RS00965 (204398)	204398..205309	+	912	WP_001168556.1	glycine--tRNA ligase subunit alpha	-
CIC27_RS00970 (205319)	205319..207388	+	2070	WP_001291738.1	glycine--tRNA ligase subunit beta	-
CIC27_RS24100 (207650)	207650..208081	+	432	Protein_193	IS3 family transposase	-
CIC27_RS00980 (208223)	208223..208690	+	468	WP_000702452.1	GNAT family N-acetyltransferase	-
CIC27_RS00985 (208868)	208868..209155	+	288	WP_000965886.1	DUF1778 domain-containing protein	Antitoxin
CIC27_RS00990 (209143)	209143..209628	+	486	WP_000533907.1	GNAT family N-acetyltransferase	Toxin
CIC27_RS00995 (209999)	209999..210538	-	540	WP_000047140.1	copper-binding periplasmic metallochaperone CueP	-
CIC27_RS01000 (210711)	210711..210923	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
CIC27_RS01005 (211211)	211211..211501	-	291	WP_000455790.1	HTH-type transcriptional regulator	-
CIC27_RS01010 (211940)	211940..212650	+	711	WP_000190524.1	DUF3053 domain-containing protein	-
CIC27_RS01015 (212700)	212700..213674	-	975	WP_000804695.1	glyoxylate/hydroxypyruvate reductase GhrB	-
CIC27_RS01020 (213904)	213904..214566	-	663	WP_000747548.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (31-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-94)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17715.46 Da
• Isoelectric Point: 9.8719

>T202887 WP_000533907.1 NZ_CP075110:209143-209628 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T202887 NZ_CP099743:c3896665-3896348 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAAATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10950.60 Da
• Isoelectric Point: 4.6811

>AT202887 WP_000965886.1 NZ_CP075110:208868-209155 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Nucleotide

• Length: 288 bp

>AT202887 NZ_CP099743:c3896355-3896068 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: A0A3V9PR68

Antitoxin

• AlphaFold DB: A0A3V2JDX2