Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 208868..209628 Replicon chromosome
Accession NZ_CP075110
Organism Salmonella enterica strain CFSAN060804

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag CIC27_RS00990 Protein ID WP_000533907.1
Coordinates 209143..209628 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag CIC27_RS00985 Protein ID WP_000965886.1
Coordinates 208868..209155 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC27_RS00960 (203957) 203957..204259 + 303 WP_000605592.1 YsaB family lipoprotein -
CIC27_RS00965 (204398) 204398..205309 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
CIC27_RS00970 (205319) 205319..207388 + 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
CIC27_RS24100 (207650) 207650..208081 + 432 Protein_193 IS3 family transposase -
CIC27_RS00980 (208223) 208223..208690 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
CIC27_RS00985 (208868) 208868..209155 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
CIC27_RS00990 (209143) 209143..209628 + 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
CIC27_RS00995 (209999) 209999..210538 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
CIC27_RS01000 (210711) 210711..210923 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CIC27_RS01005 (211211) 211211..211501 - 291 WP_000455790.1 HTH-type transcriptional regulator -
CIC27_RS01010 (211940) 211940..212650 + 711 WP_000190524.1 DUF3053 domain-containing protein -
CIC27_RS01015 (212700) 212700..213674 - 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
CIC27_RS01020 (213904) 213904..214566 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T202887 WP_000533907.1 NZ_CP075110:209143-209628 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202887 NZ_CP099743:c3896665-3896348 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAAATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT202887 WP_000965886.1 NZ_CP075110:208868-209155 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202887 NZ_CP099743:c3896355-3896068 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References