Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4257611..4258392 Replicon chromosome
Accession NZ_CP075109
Organism Salmonella enterica strain CFSAN060807

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag CIC24_RS20655 Protein ID WP_000626100.1
Coordinates 4257611..4258102 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag CIC24_RS20660 Protein ID WP_001110452.1
Coordinates 4258099..4258392 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC24_RS20620 (4253606) 4253606..4254181 + 576 WP_001188509.1 transcriptional regulator -
CIC24_RS20630 (4254452) 4254452..4254529 - 78 Protein_4052 helix-turn-helix domain-containing protein -
CIC24_RS20635 (4254620) 4254620..4254952 - 333 WP_001165472.1 MerR family transcriptional regulator -
CIC24_RS20640 (4255024) 4255024..4255401 + 378 WP_000916345.1 EthD family reductase -
CIC24_RS20645 (4256434) 4256434..4256508 + 75 Protein_4055 porin family protein -
CIC24_RS20650 (4256611) 4256611..4257363 + 753 WP_000842427.1 non-specific acid phosphatase -
CIC24_RS20655 (4257611) 4257611..4258102 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
CIC24_RS20660 (4258099) 4258099..4258392 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
CIC24_RS20665 (4258709) 4258709..4258930 + 222 WP_001654251.1 hypothetical protein -
CIC24_RS20670 (4259195) 4259195..4260070 + 876 WP_000921676.1 AraC family transcriptional regulator -
CIC24_RS20675 (4260067) 4260067..4260354 + 288 WP_001541332.1 transcriptional regulator RtsB -
CIC24_RS20680 (4260494) 4260494..4260868 + 375 WP_230320449.1 Ig-like domain-containing protein -
CIC24_RS20685 (4261163) 4261163..4262068 - 906 WP_001268198.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T202884 WP_000626100.1 NZ_CP075109:c4258102-4257611 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T202884 NZ_CP099743:796855-797265 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT202884 WP_001110452.1 NZ_CP075109:c4258392-4258099 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202884 NZ_CP099743:796608-796874 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References