Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4151978..4152494 Replicon chromosome
Accession NZ_CP075109
Organism Salmonella enterica strain CFSAN060807

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag CIC24_RS20080 Protein ID WP_000220577.1
Coordinates 4151978..4152262 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag CIC24_RS20085 Protein ID WP_000212724.1
Coordinates 4152252..4152494 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC24_RS20065 (4147094) 4147094..4148746 + 1653 WP_079798427.1 alpha,alpha-phosphotrehalase -
CIC24_RS20070 (4149155) 4149155..4151293 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
CIC24_RS20075 (4151510) 4151510..4151974 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CIC24_RS20080 (4151978) 4151978..4152262 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CIC24_RS20085 (4152252) 4152252..4152494 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CIC24_RS20090 (4152572) 4152572..4154485 - 1914 WP_001212131.1 BglG family transcription antiterminator -
CIC24_RS20095 (4154502) 4154502..4155242 - 741 WP_000779252.1 KDGP aldolase family protein -
CIC24_RS20100 (4155239) 4155239..4156357 - 1119 WP_001139178.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CIC24_RS20105 (4156341) 4156341..4157474 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T202883 WP_000220577.1 NZ_CP075109:c4152262-4151978 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202883 NZ_CP099743:376600-376947 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGACAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT202883 WP_000212724.1 NZ_CP075109:c4152494-4152252 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202883 NZ_CP099743:376947-377246 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References