Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacT-ataR/ElaA-DUF1778 |
| Location | 20466..21220 | Replicon | plasmid pXF51 |
| Accession | NC_002490 | ||
| Organism | Xylella fastidiosa 9a5c | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q9PHI0 |
| Locus tag | XF_RS12265 | Protein ID | WP_010895221.1 |
| Coordinates | 20735..21220 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | Q9PHI1 |
| Locus tag | XF_RS12260 | Protein ID | WP_010895220.1 |
| Coordinates | 20466..20738 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XF_RS12225 | 17463..17660 | + | 198 | WP_042464033.1 | hypothetical protein | - |
| XF_RS12230 | 17741..17983 | + | 243 | WP_042464081.1 | hypothetical protein | - |
| XF_RS12240 | 18343..18900 | - | 558 | WP_042464084.1 | recombinase family protein | - |
| XF_RS12245 | 18959..19243 | - | 285 | WP_143707262.1 | hypothetical protein | - |
| XF_RS12250 | 19412..19831 | - | 420 | WP_010895219.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| XF_RS12255 | 19831..20070 | - | 240 | WP_004085761.1 | ribbon-helix-helix domain-containing protein | - |
| XF_RS12260 | 20466..20738 | + | 273 | WP_010895220.1 | DUF1778 domain-containing protein | Antitoxin |
| XF_RS12265 | 20735..21220 | + | 486 | WP_010895221.1 | GNAT family N-acetyltransferase | Toxin |
| XF_RS12270 | 21694..21966 | - | 273 | WP_010895222.1 | DUF4190 domain-containing protein | - |
| XF_RS12275 | 22031..22357 | - | 327 | WP_010895223.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| XF_RS12280 | 22344..22574 | - | 231 | WP_042464041.1 | hypothetical protein | - |
| XF_RS12285 | 22854..23099 | - | 246 | Protein_27 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| XF_RS12290 | 23143..23310 | - | 168 | WP_042464043.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| XF_RS12295 | 23298..23551 | - | 254 | Protein_29 | CopG family ribbon-helix-helix protein | - |
| XF_RS12300 | 23811..24830 | - | 1020 | WP_010895227.1 | hypothetical protein | - |
| XF_RS12305 | 25191..25946 | - | 756 | WP_010895228.1 | alpha/beta hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..51158 | 51158 | |
| - | flank | IS/Tn | - | - | 18343..18900 | 557 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17895.74 Da Isoelectric Point: 9.4154
>T20288 WP_010895221.1 NC_002490:20735-21220 [Xylella fastidiosa 9a5c]
VNMQISTPHSLTAAHRLDEFNCGEPSLDDWLKRCALTNHLNGASRTFVVVDANQYVLGYYALAAGSVAHQEATRAIRRNM
PDPVPVMVLGRLAVDTRAQGIKLGAALLKDTVTRVQFIAENVGVRALVVHALNERAKQFYEYYGFRASPMHLMTLMLPIK
F
VNMQISTPHSLTAAHRLDEFNCGEPSLDDWLKRCALTNHLNGASRTFVVVDANQYVLGYYALAAGSVAHQEATRAIRRNM
PDPVPVMVLGRLAVDTRAQGIKLGAALLKDTVTRVQFIAENVGVRALVVHALNERAKQFYEYYGFRASPMHLMTLMLPIK
F
Download Length: 486 bp
>T20288 NC_002490:20735-21220 [Xylella fastidiosa 9a5c]
GTGAATATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTCGATGAATTCAATTGCGGTGAGCCATCGCT
GGATGATTGGCTTAAACGATGCGCATTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTTGTTGTCGATGCCAACC
AGTACGTGCTTGGGTACTACGCTTTGGCAGCTGGGTCTGTCGCGCATCAAGAGGCCACGCGTGCTATCCGACGTAATATG
CCTGATCCAGTGCCGGTCATGGTGCTCGGAAGGCTGGCTGTAGATACTCGCGCTCAAGGCATCAAACTCGGTGCGGCCTT
GCTTAAAGATACGGTAACTCGTGTACAGTTCATTGCAGAGAACGTCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACG
AGCGCGCAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAA
TTCTAG
GTGAATATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTCGATGAATTCAATTGCGGTGAGCCATCGCT
GGATGATTGGCTTAAACGATGCGCATTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTTGTTGTCGATGCCAACC
AGTACGTGCTTGGGTACTACGCTTTGGCAGCTGGGTCTGTCGCGCATCAAGAGGCCACGCGTGCTATCCGACGTAATATG
CCTGATCCAGTGCCGGTCATGGTGCTCGGAAGGCTGGCTGTAGATACTCGCGCTCAAGGCATCAAACTCGGTGCGGCCTT
GCTTAAAGATACGGTAACTCGTGTACAGTTCATTGCAGAGAACGTCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACG
AGCGCGCAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAA
TTCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 10237.74 Da Isoelectric Point: 4.7419
>AT20288 WP_010895220.1 NC_002490:20466-20738 [Xylella fastidiosa 9a5c]
MRDASINLRAMPEQRDLIDQAANLLGKNRSDFMLEAACERAKAIILDQVFFNLDEERFRQFTVLLDGPQDTNLGLNRLMA
IKAPWSIGNT
MRDASINLRAMPEQRDLIDQAANLLGKNRSDFMLEAACERAKAIILDQVFFNLDEERFRQFTVLLDGPQDTNLGLNRLMA
IKAPWSIGNT
Download Length: 273 bp
>AT20288 NC_002490:20466-20738 [Xylella fastidiosa 9a5c]
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTTAATCTGG
ACGAAGAGAGGTTCCGGCAATTCACTGTGTTGCTTGATGGGCCACAAGACACCAATCTCGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCGGCAATACGTGA
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTTAATCTGG
ACGAAGAGAGGTTCCGGCAATTCACTGTGTTGCTTGATGGGCCACAAGACACCAATCTCGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCGGCAATACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|