202876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3437728..3438348 Replicon chromosome
Accession NZ_CP075109
Organism Salmonella enterica strain CFSAN060807

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CIC24_RS16805 Protein ID WP_001280991.1
Coordinates 3438130..3438348 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CIC24_RS16800 Protein ID WP_000344807.1
Coordinates 3437728..3438102 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC24_RS16790 (3432867) 3432867..3434060 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CIC24_RS16795 (3434083) 3434083..3437232 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
CIC24_RS16800 (3437728) 3437728..3438102 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CIC24_RS16805 (3438130) 3438130..3438348 + 219 WP_001280991.1 HHA domain-containing protein Toxin
CIC24_RS16810 (3438527) 3438527..3439078 + 552 WP_001278791.1 maltose O-acetyltransferase -
CIC24_RS16815 (3439196) 3439196..3439666 + 471 WP_000136183.1 YlaC family protein -
CIC24_RS16820 (3439722) 3439722..3439862 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CIC24_RS16825 (3439868) 3439868..3440128 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CIC24_RS16830 (3440353) 3440353..3441903 + 1551 WP_076932570.1 EAL domain-containing protein -
CIC24_RS16840 (3442134) 3442134..3442523 + 390 WP_000961285.1 MGMT family protein -
CIC24_RS16845 (3442556) 3442556..3443125 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202876 WP_001280991.1 NZ_CP075109:3438130-3438348 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202876 NZ_CP099734:1574713-1575003 [Photobacterium sp. TY1-4]
ATGACCTATAAACTCGATTTCAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACGTTGCAACAGATGTTTAA
GAAAAAACTGATTGAGCGCCTGGAAAACCCACATGTACCAGCCTCAAAACTTTCCGGCGCTGACAACATGTATAAAATTA
AACTGCGTCAATCGGGTTACCGCTTAGTCTACAAAGTTGAAGACGATGTCGTTATTGTAACCGTCTTAGCCGTTGGAAAG
CGCGAACGTAGTGATGTTTACCGTAAGGCGATGAAACGTTCAGATGTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202876 WP_000344807.1 NZ_CP075109:3437728-3438102 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202876 NZ_CP099734:1574475-1574723 [Photobacterium sp. TY1-4]
ATGACCACTCGAATTTTAGCCGATGTCGCTGCAAGCATTACTGAGTTAAAAGCTAACCCGATGAAAGTTGCAACGAGTGC
CTACGGTGAACCTGTTGCTGTACTGAACCGAAATGAACCAGCATTTTACTGCGTACCTGCTGAAGCATACGAAATGATGA
TAGACAGACTCGAAGATCTTGAGCTACTTGCTATTGCGAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTTAACATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References