202875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2345149..2345671 Replicon chromosome
Accession NZ_CP075109
Organism Salmonella enterica strain CFSAN060807

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag CIC24_RS11300 Protein ID WP_000221345.1
Coordinates 2345387..2345671 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag CIC24_RS11295 Protein ID WP_000885424.1
Coordinates 2345149..2345397 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC24_RS11270 (2340785) 2340785..2341693 - 909 WP_079798353.1 LysR family transcriptional regulator -
CIC24_RS11275 (2342610) 2342610..2343345 + 736 Protein_2215 helix-turn-helix domain-containing protein -
CIC24_RS11280 (2343401) 2343401..2344309 - 909 WP_079798383.1 hypothetical protein -
CIC24_RS11285 (2344460) 2344460..2344792 - 333 WP_000253155.1 DUF1493 family protein -
CIC24_RS11290 (2344782) 2344782..2344997 - 216 WP_000206206.1 hypothetical protein -
CIC24_RS11295 (2345149) 2345149..2345397 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CIC24_RS11300 (2345387) 2345387..2345671 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CIC24_RS11305 (2345831) 2345831..2346220 + 390 WP_001652798.1 RidA family protein -
CIC24_RS11310 (2346272) 2346272..2347351 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
CIC24_RS11315 (2347544) 2347544..2348032 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
CIC24_RS11320 (2348077) 2348077..2349585 + 1509 WP_079798354.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2337913..2352442 14529
- flank IS/Tn - - 2342610..2343179 569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T202875 WP_000221345.1 NZ_CP075109:2345387-2345671 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T202875 NZ_CP099734:1309583-1309870 [Photobacterium sp. TY1-4]
ATGAAAGTAGTGTGGTCTCCATTAGCTTTACAGAAGCTTGGTGATGCGGCTGAATTTATCTCATTGGATAATCCAGCGGC
AGCTGGAAATTGGGTAAATGAAGTTTTCGACCAAACGGAGCTACTTGGAACCATGCCTGAAATGGGGCGTATGGTTCCAG
AAATGCCTGATACACATTATCGTGAAATCATTTTTGGTCACTATCGCATCATTTATAGTTTAAGCCATGAAATTCGCGTA
CTAACGGTGCGAAATTGTCGTCAAATCCTGACGGAAGATGACGTCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT202875 WP_000885424.1 NZ_CP075109:2345149-2345397 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT202875 NZ_CP099734:1309305-1309586 [Photobacterium sp. TY1-4]
ATGAGTCGCATTCATTTCGACAAAGATATTCAGCCTCTGTCTGAATTTCGTGCAAGCGTAGCCTCATTTATTAAGCAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACTCAACGTGGTAAAGGCGTTGCTGTTGTTCTTGATGTTGCAGAGTATGAAG
CAATGCAAGAGAAGATTGAACTACTTGAAGAAATGCGTACAGCTGAAGCTCAACTTGCGTCTGGTTTGGGTGTTTCGAAT
GAAGATGCTCGTGCTCAGGTACTGGGGCGCATCAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References