Detailed information of TA system TA202864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 819166..819791
• Replicon: chromosome
• Accession: NZ_CP075109
• Organism: Salmonella enterica strain CFSAN060807

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CIC24_RS03965
• Protein ID: WP_000911337.1
• Coordinates: 819393..819791 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: CIC24_RS03960
• Protein ID: WP_000557545.1
• Coordinates: 819166..819393 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC24_RS03930 (814262)	814262..815360	+	1099	WP_010989230.1	peptide chain release factor 2	-
CIC24_RS03935 (815370)	815370..816887	+	1518	WP_000003339.1	lysine--tRNA ligase	-
CIC24_RS03940 (816963)	816963..817508	-	546	WP_050067887.1	isopentenyl-diphosphate Delta-isomerase	-
CIC24_RS03945 (817773)	817773..818531	+	759	WP_000244328.1	amidase activator ActS	-
CIC24_RS03955 (818777)	818777..818989	-	213	WP_024152440.1	hypothetical protein	-
CIC24_RS03960 (819166)	819166..819393	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
CIC24_RS03965 (819393)	819393..819791	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CIC24_RS03970 (820600)	820600..821136	+	537	WP_001038503.1	STM3031 family outer membrane protein	-
CIC24_RS03975 (821183)	821183..821815	+	633	WP_000835265.1	YfdX family protein	-
CIC24_RS03980 (822534)	822534..823121	+	588	WP_001244643.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	818777..828939	10162

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T202864 WP_000911337.1 NZ_CP075109:819393-819791 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T202864 NZ_CP099721:c4707534-4707223 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT202864 WP_000557545.1 NZ_CP075109:819166-819393 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT202864 NZ_CP099721:c4707222-4706932 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6