Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 809438..810098 Replicon chromosome
Accession NZ_CP075109
Organism Salmonella enterica strain CFSAN060807

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag CIC24_RS03905 Protein ID WP_000244761.1
Coordinates 809685..810098 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag CIC24_RS03900 Protein ID WP_000351186.1
Coordinates 809438..809704 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC24_RS03880 (805366) 805366..806799 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
CIC24_RS03885 (806958) 806958..807269 + 312 WP_001182970.1 N(4)-acetylcytidine aminohydrolase -
CIC24_RS03890 (807433) 807433..808092 + 660 WP_000250289.1 hemolysin III family protein -
CIC24_RS03895 (808208) 808208..809188 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
CIC24_RS03900 (809438) 809438..809704 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
CIC24_RS03905 (809685) 809685..810098 + 414 WP_000244761.1 protein YgfX Toxin
CIC24_RS03910 (810151) 810151..810672 - 522 WP_001055885.1 flavodoxin FldB -
CIC24_RS03915 (810785) 810785..811681 + 897 WP_000434299.1 site-specific tyrosine recombinase XerD -
CIC24_RS03920 (811705) 811705..812418 + 714 WP_000745615.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CIC24_RS03925 (812424) 812424..814157 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T202863 WP_000244761.1 NZ_CP075109:809685-810098 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T202863 NZ_CP099721:c4401427-4401254 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202863 WP_000351186.1 NZ_CP075109:809438-809704 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202863 NZ_CP099721:c4401751-4401455 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References