Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 188575..189335 Replicon chromosome
Accession NZ_CP075109
Organism Salmonella enterica strain CFSAN060807

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag CIC24_RS00880 Protein ID WP_000533909.1
Coordinates 188850..189335 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag CIC24_RS00875 Protein ID WP_000965886.1
Coordinates 188575..188862 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC24_RS00855 (183980) 183980..184891 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
CIC24_RS00860 (184901) 184901..186970 + 2070 WP_001291739.1 glycine--tRNA ligase subunit beta -
CIC24_RS22915 (187360) 187360..187758 + 399 Protein_171 IS3 family transposase -
CIC24_RS00870 (187930) 187930..188397 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
CIC24_RS00875 (188575) 188575..188862 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
CIC24_RS00880 (188850) 188850..189335 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
CIC24_RS00885 (189706) 189706..190245 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
CIC24_RS00890 (190419) 190419..190631 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CIC24_RS00895 (190920) 190920..191210 - 291 WP_000455790.1 HTH-type transcriptional regulator -
CIC24_RS00900 (191649) 191649..192359 + 711 WP_000190524.1 DUF3053 domain-containing protein -
CIC24_RS00905 (192409) 192409..193383 - 975 WP_000804683.1 glyoxylate/hydroxypyruvate reductase GhrB -
CIC24_RS00910 (193602) 193602..194264 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T202862 WP_000533909.1 NZ_CP075109:188850-189335 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202862 NZ_CP099721:4160651-4160908 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT202862 WP_000965886.1 NZ_CP075109:188575-188862 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202862 NZ_CP099721:4160920-4161465 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCTTTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References