Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4169309..4170090 Replicon chromosome
Accession NZ_CP075108
Organism Salmonella enterica strain CFSAN060808

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag CIC23_RS20150 Protein ID WP_000626100.1
Coordinates 4169309..4169800 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag CIC23_RS20155 Protein ID WP_001110452.1
Coordinates 4169797..4170090 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC23_RS20115 (4164769) 4164769..4165116 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
CIC23_RS20120 (4165092) 4165092..4166795 + 1704 WP_000068883.1 protein-disulfide reductase DsbD -
CIC23_RS20125 (4166832) 4166832..4167407 + 576 WP_001188509.1 transcriptional regulator -
CIC23_RS20135 (4167678) 4167678..4167752 - 75 Protein_3960 helix-turn-helix domain-containing protein -
CIC23_RS20140 (4168132) 4168132..4168209 + 78 Protein_3961 porin family protein -
CIC23_RS20145 (4168309) 4168309..4169061 + 753 WP_000842424.1 non-specific acid phosphatase -
CIC23_RS20150 (4169309) 4169309..4169800 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
CIC23_RS20155 (4169797) 4169797..4170090 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
CIC23_RS20160 (4170405) 4170405..4170626 + 222 WP_001576552.1 hypothetical protein -
CIC23_RS20165 (4170892) 4170892..4171767 + 876 WP_000921676.1 AraC family transcriptional regulator -
CIC23_RS20170 (4171764) 4171764..4172051 + 288 WP_001269916.1 transcriptional regulator RtsB -
CIC23_RS20175 (4172074) 4172074..4172289 + 216 WP_001595136.1 hypothetical protein -
CIC23_RS20180 (4172297) 4172297..4172566 + 270 WP_077912342.1 hypothetical protein -
CIC23_RS20185 (4172859) 4172859..4173764 - 906 WP_038390009.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T202859 WP_000626100.1 NZ_CP075108:c4169800-4169309 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T202859 NZ_CP099721:c3711250-3710852 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT202859 WP_001110452.1 NZ_CP075108:c4170090-4169797 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202859 NZ_CP099721:c3711546-3711253 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References