Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 812556..813181 Replicon chromosome
Accession NZ_CP075108
Organism Salmonella enterica strain CFSAN060808

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CIC23_RS03915 Protein ID WP_000911337.1
Coordinates 812783..813181 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag CIC23_RS03910 Protein ID WP_000557549.1
Coordinates 812556..812783 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC23_RS03880 (807647) 807647..808745 + 1099 WP_010989230.1 peptide chain release factor 2 -
CIC23_RS03885 (808755) 808755..810272 + 1518 WP_000003339.1 lysine--tRNA ligase -
CIC23_RS03890 (810348) 810348..810893 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
CIC23_RS03895 (811158) 811158..811916 + 759 WP_000244328.1 amidase activator ActS -
CIC23_RS03905 (812143) 812143..812379 - 237 WP_220541995.1 hypothetical protein -
CIC23_RS03910 (812556) 812556..812783 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
CIC23_RS03915 (812783) 812783..813181 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
CIC23_RS03920 (813986) 813986..814522 + 537 WP_001038502.1 STM3031 family outer membrane protein -
CIC23_RS03925 (814569) 814569..815201 + 633 WP_000835265.1 YfdX family protein -
CIC23_RS03930 (815920) 815920..816507 + 588 WP_001244643.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 812143..822328 10185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T202844 WP_000911337.1 NZ_CP075108:812783-813181 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T202844 NZ_CP099721:178110-178217 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT202844 WP_000557549.1 NZ_CP075108:812556-812783 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT202844 NZ_CP099721:c178061-177996 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References