Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 802823..803483 Replicon chromosome
Accession NZ_CP075108
Organism Salmonella enterica strain CFSAN060808

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag CIC23_RS03855 Protein ID WP_000244756.1
Coordinates 803070..803483 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag CIC23_RS03850 Protein ID WP_000351186.1
Coordinates 802823..803089 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC23_RS03830 (798751) 798751..800184 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
CIC23_RS03835 (800343) 800343..800654 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
CIC23_RS03840 (800818) 800818..801477 + 660 WP_023261364.1 hemolysin III family protein -
CIC23_RS03845 (801593) 801593..802573 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
CIC23_RS03850 (802823) 802823..803089 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
CIC23_RS03855 (803070) 803070..803483 + 414 WP_000244756.1 protein YgfX Toxin
CIC23_RS03860 (803536) 803536..804057 - 522 WP_001055885.1 flavodoxin FldB -
CIC23_RS03865 (804170) 804170..805066 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
CIC23_RS03870 (805090) 805090..805803 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CIC23_RS03875 (805809) 805809..807542 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T202843 WP_000244756.1 NZ_CP075108:803070-803483 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T202843 NZ_CP099721:177628-177735 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202843 WP_000351186.1 NZ_CP075108:802823-803089 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202843 NZ_CP099721:c177571-177514 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References