Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3901576..3902092 Replicon chromosome
Accession NZ_CP075107
Organism Salmonella enterica strain CFSAN060809

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag CIC22_RS18650 Protein ID WP_000220578.1
Coordinates 3901576..3901860 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag CIC22_RS18655 Protein ID WP_000212724.1
Coordinates 3901850..3902092 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC22_RS18635 (3896692) 3896692..3898344 + 1653 WP_000155039.1 alpha,alpha-phosphotrehalase -
CIC22_RS18640 (3898753) 3898753..3900891 + 2139 WP_000187827.1 anaerobic ribonucleoside-triphosphate reductase -
CIC22_RS18645 (3901108) 3901108..3901572 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CIC22_RS18650 (3901576) 3901576..3901860 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CIC22_RS18655 (3901850) 3901850..3902092 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CIC22_RS18660 (3902170) 3902170..3904083 - 1914 WP_001212145.1 BglG family transcription antiterminator -
CIC22_RS18665 (3904100) 3904100..3904840 - 741 WP_000779262.1 KDGP aldolase family protein -
CIC22_RS18670 (3904837) 3904837..3905955 - 1119 WP_001139165.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CIC22_RS18675 (3905939) 3905939..3907072 - 1134 WP_000459952.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T202839 WP_000220578.1 NZ_CP075107:c3901860-3901576 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202839 NZ_CP099715:c8037-7780 [Dietzia kunjamensis]
ATGAAGACAATGAGCTACACCGAGTCCCGGGCCCGCTACGCCGAGGTCCTCGACGGGGTCACCAACGACCGCGAAGAGGT
CATCATCACCCGCGCCGGCCACGAACCGGTGGTGATGGTCTCCCTCGACGAGTACGAGTCCCTGCGCGAGACCGCCCACC
TCATGCGATCACCGGCCAACGCCCGACGCTTGCTCGATGCGATGGAGCGGCTCGAGTCCGGCCGCGGACAGGCACGCGAC
CTGCTCGACGCCGACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT202839 WP_000212724.1 NZ_CP075107:c3902092-3901850 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202839 NZ_CP099715:c7778-7521 [Dietzia kunjamensis]
GTGCTGCTCGTCTGGGACGACAACGCCTGGCAGGACTACCTCTGGTGGCAACAACAGGACCGCAAGATCCTCAAACGCAT
CAACCTGCTCCTGCAGGACATCACCCGCAACGGCAATGAAGGAATCGGCAAACCCGAACCCCTCAAGTACGACTTCGCCG
GATACTGGTCCAGACGCATCACCGACGAGCACCGACTCGTCTACAAAGTCACCGACACCGAAGTCCGAATCGCCACCTGC
CGCTACCACTACGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References