Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3229264..3229884 Replicon chromosome
Accession NZ_CP075107
Organism Salmonella enterica strain CFSAN060809

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CIC22_RS15550 Protein ID WP_001280991.1
Coordinates 3229666..3229884 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CIC22_RS15545 Protein ID WP_000344807.1
Coordinates 3229264..3229638 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC22_RS15535 (3224403) 3224403..3225596 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CIC22_RS15540 (3225619) 3225619..3228768 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
CIC22_RS15545 (3229264) 3229264..3229638 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CIC22_RS15550 (3229666) 3229666..3229884 + 219 WP_001280991.1 HHA domain-containing protein Toxin
CIC22_RS15555 (3230063) 3230063..3230614 + 552 WP_001278791.1 maltose O-acetyltransferase -
CIC22_RS15560 (3230732) 3230732..3231202 + 471 WP_000136183.1 YlaC family protein -
CIC22_RS15565 (3231258) 3231258..3231398 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CIC22_RS15570 (3231404) 3231404..3231664 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CIC22_RS15575 (3231889) 3231889..3233439 + 1551 WP_000213134.1 EAL domain-containing protein -
CIC22_RS15585 (3233670) 3233670..3234059 + 390 WP_000961285.1 MGMT family protein -
CIC22_RS15590 (3234092) 3234092..3234661 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202835 WP_001280991.1 NZ_CP075107:3229666-3229884 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202835 NZ_CP099712:1200041-1200307 [Dietzia kunjamensis]
GTGGAGGACTACGAGCTCGTCGTCGCCCCACCCGCGGCTCGGGCGATCCAGCGGGGCCTTCCGGAGAAAATCGCCGCGGC
GGTGGTCGAATTCCTCACCGGGCCACTGATCGCGAACCCACGGCGAGCGGGAAACGAACTGCGCAGGGAGCTGACCGGCG
TGTACTTCGCTCGTCGCGGGACCTACCGCATCCTGTATCGGATCGACGACGACGCCAGAGAGGTCCTCGTTCTCCGGGTC
GAGCACAGACGGGATGTGTATCGGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202835 WP_000344807.1 NZ_CP075107:3229264-3229638 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202835 NZ_CP099712:1199766-1200032 [Dietzia kunjamensis]
ATGTCTACCGAGCCGCTCCGTGATGTCCGGGCCAACTTCAGCGACGTGGTCGACCGTGTCTCCAAGCACCACGAGCGCGT
CACGGTGACCAAGAACGGACGTCCGGTGGCCGTGGTCATGAGCCCGGACGATCTCGCCGCTCTCGAGGAGACCCTCGATG
TCCTCTCCGACCCGTCAGCGTTGGCGGATATCCAGGAGGCCGATGCGGCGAGGACGCACGGAGAGGTCGTGCGCGGCGTC
GATGCCGTCCGGGCCCTCCGCCCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References