Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-DUF971
Location 1624326..1624930 Replicon chromosome
Accession NC_002488
Organism Xylella fastidiosa 9a5c

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag XF_RS07275 Protein ID WP_042463224.1
Coordinates 1624628..1624930 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag XF_RS07270 Protein ID WP_004089254.1
Coordinates 1624326..1624631 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XF_RS14075 (XF1693) 1620190..1620366 + 177 WP_088371569.1 Blp family class II bacteriocin -
XF_RS13320 (XF1694) 1620400..1620588 + 189 WP_010894166.1 hypothetical protein -
XF_RS13325 (XF1695) 1620593..1620778 - 186 WP_209320000.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
XF_RS07235 1620816..1621091 - 276 WP_042463219.1 type II toxin-antitoxin system RelE/ParE family toxin -
XF_RS07240 (XF1696) 1621075..1621365 - 291 WP_196432179.1 CopG family transcriptional regulator -
XF_RS07245 (XF1697) 1621413..1622183 + 771 WP_010894169.1 hypothetical protein -
XF_RS07250 (XF1698) 1622183..1622500 + 318 WP_010894170.1 hypothetical protein -
XF_RS07255 (XF1699) 1622497..1623327 + 831 WP_010894171.1 hypothetical protein -
XF_RS07260 (XF1700) 1623324..1623965 + 642 WP_010894172.1 hypothetical protein -
XF_RS07265 (XF1701) 1623962..1624315 + 354 WP_010894173.1 hypothetical protein -
XF_RS07270 (XF1702) 1624326..1624631 - 306 WP_004089254.1 putative addiction module antidote protein Antitoxin
XF_RS07275 (XF1703) 1624628..1624930 - 303 WP_042463224.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XF_RS07280 (XF1704) 1625029..1626174 + 1146 WP_042463227.1 baseplate J/gp47 family protein -
XF_RS07285 (XF1705) 1626171..1626731 + 561 WP_010894176.1 DUF2612 domain-containing protein -
XF_RS07290 (XF1706) 1626735..1627898 + 1164 WP_010894177.1 phage tail protein -
XF_RS07295 (XF1707) 1627931..1628410 - 480 WP_010894178.1 hypothetical protein -
XF_RS14665 1629308..1629559 - 252 Protein_1426 HigA family addiction module antidote protein -
XF_RS07305 (XF1709) 1629510..1629865 - 356 Protein_1427 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-95)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11048.87 Da        Isoelectric Point: 9.6861

>T20283 WP_042463224.1 NC_002488:c1624930-1624628 [Xylella fastidiosa 9a5c]
MVELIKTSTFDAWINSLRDRKAAARIQARLDRLALGNPGDVKPVGAGISEMRIDHGPGYRIYFMKHGAVLILLLCGGDKS
SQMRDIEQAKALAALWKDEP

Download         Length: 303 bp

>T20283 NC_002488:c1624930-1624628 [Xylella fastidiosa 9a5c]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTGCTTTGCGGTGGCGATAAATCG
TCACAAATGCGAGATATCGAGCAGGCCAAGGCACTGGCTGCACTGTGGAAGGATGAGCCATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10983.37 Da        Isoelectric Point: 5.0941

>AT20283 WP_004089254.1 NC_002488:c1624631-1624326 [Xylella fastidiosa 9a5c]
MNNETFSRYDTADYLKTEEDIAAYMEAVMEEGGRDNPAFIARALGAVARARNLSQLARDVGMSRQGLDKALSNDGNPSFS
TILKVAKALGLRMSFTPSSMS

Download         Length: 306 bp

>AT20283 NC_002488:c1624631-1624326 [Xylella fastidiosa 9a5c]
ATGAATAATGAGACGTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAAGCACTCTCTAATGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAGGCGCTTGGTTTACGGATGTCATTCACTCCTTCCTCTATGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References