Detailed information of TA system TA202826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 961724..962538
• Replicon: chromosome
• Accession: NZ_CP075107
• Organism: Salmonella enterica strain CFSAN060809

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: CIC22_RS04570
• Protein ID: WP_220541854.1
• Coordinates: 961724..962251 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: CIC22_RS04575
• Protein ID: WP_000855694.1
• Coordinates: 962248..962538 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC22_RS04550 (957022)	957022..959589	-	2568	WP_001005808.1	DNA mismatch repair protein MutS	-
CIC22_RS04555 (959748)	959748..960269	+	522	WP_000858986.1	hypothetical protein	-
CIC22_RS04560 (960443)	960443..961099	-	657	WP_000420445.1	protein-serine/threonine phosphatase	-
CIC22_RS04565 (961446)	961446..961651	+	206	Protein_895	IS5/IS1182 family transposase	-
CIC22_RS04570 (961724)	961724..962251	-	528	WP_220541854.1	GNAT family N-acetyltransferase	Toxin
CIC22_RS04575 (962248)	962248..962538	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
CIC22_RS04580 (962808)	962808..962997	-	190	Protein_898	IS3 family transposase	-
CIC22_RS04585 (963238)	963238..963564	+	327	WP_000393302.1	hypothetical protein	-
CIC22_RS04590 (963841)	963841..964188	-	348	WP_001555786.1	DUF1493 family protein	-
CIC22_RS04595 (964173)	964173..964622	-	450	WP_000381617.1	hypothetical protein	-
CIC22_RS04600 (965054)	965054..965497	-	444	WP_000715100.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
CIC22_RS04605 (965954)	965954..966604	+	651	WP_023217563.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	960443..971917	11474
	-	flank	IS/Tn	-	-	961511..961651	140

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19071.88 Da
• Isoelectric Point: 9.6420

>T202826 WP_220541854.1 NZ_CP075107:c962251-961724 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYATLSASGRL

Nucleotide

• Length: 528 bp

>T202826 NZ_CP099705:2103413-2103516 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT202826 WP_000855694.1 NZ_CP075107:c962538-962248 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT202826 NZ_CP099705:c2103518-2103373 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7