202822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4613646..4614262 Replicon chromosome
Accession NZ_CP075106
Organism Salmonella enterica strain CFSAN064276

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CBI76_RS22320 Protein ID WP_023243564.1
Coordinates 4613646..4614020 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag CBI76_RS22325 Protein ID WP_001523745.1
Coordinates 4614020..4614262 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBI76_RS22305 (4611148) 4611148..4612050 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
CBI76_RS22310 (4612047) 4612047..4612682 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
CBI76_RS22315 (4612679) 4612679..4613608 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
CBI76_RS22320 (4613646) 4613646..4614020 - 375 WP_023243564.1 type II toxin-antitoxin system VapC family toxin Toxin
CBI76_RS22325 (4614020) 4614020..4614262 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
CBI76_RS22330 (4614467) 4614467..4615396 + 930 WP_001162860.1 alpha/beta hydrolase -
CBI76_RS22335 (4615482) 4615482..4615793 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
CBI76_RS22340 (4615790) 4615790..4616236 + 447 WP_031609809.1 type II toxin-antitoxin system HigA family antitoxin -
CBI76_RS22345 (4616251) 4616251..4617192 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
CBI76_RS22350 (4617237) 4617237..4617674 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
CBI76_RS22355 (4617671) 4617671..4618543 - 873 WP_000921423.1 virulence factor BrkB family protein -
CBI76_RS22360 (4618537) 4618537..4619136 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13880.13 Da        Isoelectric Point: 7.3567

>T202822 WP_023243564.1 NZ_CP075106:c4614020-4613646 [Salmonella enterica]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMAGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

>T202822 NZ_CP099705:365014-365289 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT202822 WP_001523745.1 NZ_CP075106:c4614262-4614020 [Salmonella enterica]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT202822 NZ_CP099705:364751-365011 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References